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Type: Journal article
Title: Genetic and clinical contributions to cerebral palsy: A multi-variable analysis
Author: O'Callaghan, M.
MacLennan, A.
Gibson, C.
McMichael, G.
Haan, E.
Broadbent, J.
Baghurst, P.
Goldwater, P.
Dekker, G.
Citation: Journal of Paediatrics and Child Health, 2013; 49(7):575-581
Publisher: Blackwell Publishing Asia
Issue Date: 2013
ISSN: 1034-4810
Statement of
Michael E O’Callaghan, Alastair H MacLennan, Catherine S Gibson, Gai L McMichael, Eric A Haan, Jessica L Broadbent, Peter A Baghurst, Paul N Goldwater, Gustaaf A Dekker and for the Australian Collaborative Cerebral Palsy Research Group
Abstract: <h4>Aim</h4>This study aims to examine single nucleotide polymorphism (SNP) associations with cerebral palsy in a multi-variable analysis adjusting for potential clinical confounders and to assess SNP-SNP and SNP-maternal infection interactions as contributors to cerebral palsy.<h4>Methods</h4>A case control study including 587 children with cerebral palsy and 1154 control children without cerebral palsy. Thirty-nine candidate SNPs were genotyped in both mother and child. Data linkage to perinatal notes and cerebral palsy registers was performed with a supplementary maternal pregnancy questionnaire. History of known maternal infection during pregnancy was extracted from perinatal databases.<h4>Results</h4>Both maternal and fetal carriage of inducible nitric oxide synthase SNP rs1137933 were significantly negatively associated with cerebral palsy in infants born at less than 32 weeks gestation after adjustment for potential clinical confounders and correction for multiple testing (odds ratio 0.55, 95% confidence interval 0.38-0.79; odds ratio 0.57, 95% confidence interval 0.4-0.82, respectively). Analysis did not show any statistically significant SNP-SNP or SNP-maternal infection interactions after correction for multiple testing.<h4>Conclusions</h4>Maternal and child inducible nitric oxide synthase SNPs are associated with reduced risk of cerebral palsy in infants born very preterm. There was no evidence for statistically significant SNP-SNP or SNP-maternal infection interactions as modulators of cerebral palsy risk.
Keywords: case control
cerebral palsy
Description: All authors are contributors to the Australian Collaborative Cerebral Palsy Research Group The definitive version is available at
Rights: © 2013 The Authors.
DOI: 10.1111/jpc.12279
Appears in Collections:Aurora harvest 4
Cerebral Palsy Research Group publications
Obstetrics and Gynaecology publications

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