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Type: Journal article
Title: Single-nucleotide polymorphism associations with preterm delivery: a case-control replication study and meta-analysis
Author: O'Callaghan, M.
MacLennan, A.
McMichael, G.
Haan, E.
Dekker, G.
Citation: Pediatric Research, 2013; 74(4):433-438
Publisher: Int Pediatric Research Foundation Inc
Issue Date: 2013
ISSN: 0031-3998
Statement of
Michael E. O’Callaghan, Alastair H. MacLennan, Gai L. McMichael, Eric A. Haan and Gustaaf A. Dekker
Abstract: <h4>Background</h4>The aim of this study was to replicate single-nucleotide polymorphism (SNP) associations with preterm birth (PTB; birth at <37 completed weeks of gestation) and synthesize currently available evidence using meta-analysis.<h4>Methods</h4>Spontaneous PTB cases and controls were selected from an existing cohort. Candidate SNPs were taken from an existing genotype panel. A systematic review was conducted for each SNP in the panel to determine suitability as a PTB candidate. Those with significant associations previously reported in Caucasians were selected for replication. Candidate SNPs were already genotyped in cases and controls and clinical data were accessed from state perinatal and cerebral palsy databases. Association analysis was conducted between each SNP and PTB, and meta-analysis was conducted if there were ≥ 3 studies in the literature. Maternal and fetal SNPs were considered as separate candidates.<h4>Results</h4>A cohort of 170 cases and 583 controls was formed. Eight SNPs from the original panel of genotyped SNPs were selected as PTB candidates and for replication on the basis of systematic literature review results. In our cohort, fetal factor V Leiden (FVL) was significantly associated with PTB (odds ratio (OR): 2.6, 95% confidence interval (CI): 1.31-5.17), and meta-analysis confirmed this association (OR: 2.71, 95% CI: 1.15-6.4).<h4>Conclusion</h4>Replication and meta-analysis support an increased risk of PTB in Caucasians with the fetal FVL mutation.
Keywords: Fetus
Premature Birth
Factor V
Odds Ratio
Case-Control Studies
Cohort Studies
Polymorphism, Single Nucleotide
White People
Rights: Copyright © 2013 International Pediatric Research Foundation, Inc.
DOI: 10.1038/pr.2013.117
Published version:
Appears in Collections:Aurora harvest 4
Cerebral Palsy Research Group publications
Obstetrics and Gynaecology publications

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