Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/80465
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Type: Journal article
Title: The balance between human maternal plasma angiotensin II and angiotensin 1-7 levels in early gestation pregnancy is influenced by fetal sex
Author: Sykes, S.
Pringle, K.
Zhou, A.
Dekker, G.
Roberts, C.
Lumbers, E.
Citation: Journal of Renin-Angiotensin-Aldosterone System, 2014; 15(4):523-531
Publisher: Sage Publications
Issue Date: 2014
ISSN: 1470-3203
1752-8976
Statement of
Responsibility: 
Shane D Sykes, Kirsty G Pringle, Ang Zhou, Gustaaf A Dekker, Claire T Roberts and Eugenie R Lumbers on behalf of the SCOPE Consortium
Abstract: There are fetal sex-associated differences in the circulating maternal renin-angiotensin system (RAS) in early pregnancy.Plasma prorenin, angiotensin (Ang) II, Ang 1-7 and angiotensin-converting enzyme (ACE) concentrations were measured at 15 weeks' gestation in 131 women with uncomplicated pregnancies from the Adelaide SCOPE cohort. Uterine and umbilical artery Doppler sonography was performed at 20 weeks' gestation.At 15 weeks, women bearing female fetuses had higher maternal Ang II concentrations (p = 0.017) and lower Ang 1-7 to Ang II ratios (p = 0.016) than women bearing males. In women with male fetuses, Ang II positively correlated with birth weight (p = 0.028) and prorenin negatively correlated with placental weight (p = 0.014). Female fetuses had higher umbilical artery resistance indices (p = 0.019) that were related to maternal prorenin concentrations (p = 0.007).In early human pregnancy, the maternal RAS is influenced by fetal sex. The lower Ang 1-7 to Ang II ratios in women with female fetuses may contribute to the lower maternal peripheral microvascular flow as described previously and the lack of any positive effect of Ang II on fetal growth, as seen in women with male fetuses.
Keywords: Pregnancy; sexual dimorphism; prorenin; angiotensin-converting enzyme; angiotensin peptides
Rights: © The Author(s) 2013
RMID: 0020131685
DOI: 10.1177/1470320313477174
Grant ID: http://purl.org/au-research/grants/nhmrc/1020749
http://purl.org/au-research/grants/nhmrc/565320
Appears in Collections:Obstetrics and Gynaecology publications

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