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https://hdl.handle.net/2440/80748
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Type: | Journal article |
Title: | Changes in endothelial function and depression scores are associated following long-term dietary intervention: A secondary analysis |
Author: | Moran, L. Wilson, C. Buckley, J. Noakes, M. Clifton, P. Brinkworth, G. |
Citation: | Nutrition, 2013; 29(10):1271-1274 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2013 |
ISSN: | 0899-9007 1873-1244 |
Statement of Responsibility: | Lisa J. Moran, Carlene J. Wilson, Jonathan D. Buckley, Manny Noakes, Peter M. Clifton, Grant D. Brinkworth |
Abstract: | <h4>Objective</h4>Cross-sectional studies show associations between depression and endothelial function (as measured by endothelium-dependent brachial artery flow-mediated dilatation [FMD]); but it is not known whether changes in these parameters are associated following dietary management. We have previously reported that compared with consumption of a high-carbohydrate (HC) diet, despite comparable weight loss, a very low-carbohydrate (LC diet) impaired FMD and increased depression. The purpose of this study was to conduct a secondary analysis to examine whether there was an association between changes in FMD and depression.<h4>Methods</h4>Forty-seven overweight men and women (body mass index 26-43 kg/m(2) and ages 24-64 y) completed a 12-mo randomized controlled trial during which participants consumed either an energy-restricted, isocaloric LC or HC diet. Weight, body composition, Homeostasis Assessment of Insulin Resistance (HOMA), depression (Beck Depression Inventory [BDI]), Anxiety (Spielberger State-Trait Anxiety Inventory [STAI]) and FMD were assessed before and after the intervention. This secondary analysis focused on multiple regression analysis of these parameters.<h4>Results</h4>Changes in BDI were independently predicted by changes in FMD (β = -0.356; P = 0.026) but not by diet intervention assignment or changes in weight or HOMA. No variables were significant predictors of the change in STAI.<h4>Conclusions</h4>Over time, impairments in FMD were independently associated with increased depression, independent of diet composition, or changes in weight and insulin resistance. This data supports a mechanistic association between depression and endothelial function, which may influence long-term health. |
Keywords: | Depression endothelial function diet |
Rights: | © 2013 Elsevier Inc |
DOI: | 10.1016/j.nut.2013.03.023 |
Published version: | http://dx.doi.org/10.1016/j.nut.2013.03.023 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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