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https://hdl.handle.net/2440/81470
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Type: | Journal article |
Title: | Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model |
Author: | Mrozik, K. Wada, N. Marino, V. Richter, W. Shi, S. Wheeler, D. Gronthos, S. Bartold, P. |
Citation: | Regenerative Medicine, 2013; 8(6):711-723 |
Publisher: | Future Medicine Ltd |
Issue Date: | 2013 |
ISSN: | 1746-0751 1746-076X |
Statement of Responsibility: | Krzysztof Marek Mrozik, Naohisa Wada, Victor Marino, Ward Richter, Songtao Shi, Donna L Wheeler, Stan Gronthos, and P Mark Bartold |
Abstract: | Aim: To investigate the capacity of allogeneic periodontal ligament stem cells (PDLSCs) to regenerate periodontal tissues using an ovine periodontal defect model. Materials & methods: Surgically created zero-wall dehiscence periodontal defects created in Merino sheep were filled with 1 × 107 allogeneic PDLSCs attached to Gelfoam®, Gelfoam alone or left untreated. After 4 weeks, histological analysis was performed to assess periodontal regeneration. Results: Allogeneic PDLSCs were well tolerated by recipient animals. The mean area of new alveolar bone was significantly greater in the PDLSC + Gelfoam treatment group compared with the defect-alone group. The PDLSC + Gelfoam and Gelfoam-only treatment groups displayed significantly greater length of new cementum and percentage of cementum regrowth compared with the defect-alone group. New Sharpey‘s fibers were generally more organized and significantly thicker within the PDLSC + Gelfoam treatment group. The PDLSC + Gelfoam treatment group also showed a trend of increased Sharpey‘s fiber attachment length compared with the Gelfoam-only and defect-alone groups. Conclusion: These studies support the potential use of allogeneic PDLSC preparations as viable therapies for periodontal regeneration in the clinical setting. |
Keywords: | allogeneic alveolar bone cementum periodontal ligament stem cells regeneration Sharpey‘s fibers |
Rights: | © Future Medicine |
DOI: | 10.2217/rme.13.66 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/299009 http://purl.org/au-research/grants/nhmrc/453599 |
Published version: | http://dx.doi.org/10.2217/rme.13.66 |
Appears in Collections: | Aurora harvest 4 Dentistry publications |
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