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Type: Journal article
Title: Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model
Author: Mrozik, K.
Wada, N.
Marino, V.
Richter, W.
Shi, S.
Wheeler, D.
Gronthos, S.
Bartold, P.
Citation: Regenerative Medicine, 2013; 8(6):711-723
Publisher: Future Medicine Ltd
Issue Date: 2013
ISSN: 1746-0751
Statement of
Krzysztof Marek Mrozik, Naohisa Wada, Victor Marino, Ward Richter, Songtao Shi, Donna L Wheeler, Stan Gronthos, and P Mark Bartold
Abstract: Aim: To investigate the capacity of allogeneic periodontal ligament stem cells (PDLSCs) to regenerate periodontal tissues using an ovine periodontal defect model. Materials & methods: Surgically created zero-wall dehiscence periodontal defects created in Merino sheep were filled with 1 × 107 allogeneic PDLSCs attached to Gelfoam®, Gelfoam alone or left untreated. After 4 weeks, histological analysis was performed to assess periodontal regeneration. Results: Allogeneic PDLSCs were well tolerated by recipient animals. The mean area of new alveolar bone was significantly greater in the PDLSC + Gelfoam treatment group compared with the defect-alone group. The PDLSC + Gelfoam and Gelfoam-only treatment groups displayed significantly greater length of new cementum and percentage of cementum regrowth compared with the defect-alone group. New Sharpey‘s fibers were generally more organized and significantly thicker within the PDLSC + Gelfoam treatment group. The PDLSC + Gelfoam treatment group also showed a trend of increased Sharpey‘s fiber attachment length compared with the Gelfoam-only and defect-alone groups. Conclusion: These studies support the potential use of allogeneic PDLSC preparations as viable therapies for periodontal regeneration in the clinical setting.
Keywords: allogeneic; alveolar bone; cementum; periodontal ligament stem cells; regeneration; Sharpey‘s fibers
Rights: © Future Medicine
RMID: 0020132553
DOI: 10.2217/rme.13.66
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Appears in Collections:Dentistry publications

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