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Type: Journal article
Title: Tissue and circulating microRNA influence reproductive function in endometrial disease
Author: Hull, M.
Nisenblat, V.
Citation: Reproductive Biomedicine Online, 2013; 27(5):515-529
Publisher: Reproductive Healthcare Ltd.
Issue Date: 2013
ISSN: 1472-6483
Statement of
M Louise Hull, Victoria Nisenblat
Abstract: microRNA (miRNA) have emerged as important epigenetic modulators of gene expression in diverse pathological and physiological processes. In the endometrium, miRNA appear to have a role in the dynamic changes associated with the menstrual cycle, in implantation and in the pathophysiology associated with reproductive disorders such as recurrent miscarriage and endometriosis. This review explores the role of miRNA in endometrial physiology and endometrial disorders of reproduction and also raises the prospect that circulating miRNA may modulate endometrial function or reflect disordered endometrial activity. The clinical potential to use miRNA in diagnostic tests of endometrial function or in the treatment of endometrial disorders will also be discussed.
Keywords: endometriosis
Rights: © 2013, Reproductive Healthcare Ltd.
DOI: 10.1016/j.rbmo.2013.07.012
Appears in Collections:Aurora harvest 4
Obstetrics and Gynaecology publications

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