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Type: Journal article
Title: Is the human chorionic gonadotrophin secreted by ectopic trophoblast different from that in normal intrauterine pregnancies?
Author: Buck, R.
Moodley, J.
Norman, R.
Citation: Fertility and Sterility, 1995; 64(4):724-729
Publisher: American Fertility Society
Issue Date: 1995
ISSN: 0015-0282
Abstract: <h4>Objective</h4>To determine whether different isoforms of hCG are secreted by trophoblast tissue from ectopic pregnancy (EP).<h4>Design</h4>Retrospective study of surgically confirmed EPs compared with normal pregnancies.<h4>Setting</h4>Teaching hospital in South Africa.<h4>Patients</h4>One hundred patients with EPs and 120 patients with normal pregnancies.<h4>Main outcome measures</h4>Isoforms of hCG were measured by specific immunoassays, lectin binding, and examination of disappearance rates of hCG after surgical clearance of EP.<h4>Results</h4>There were no obvious differences between the two types of pregnancy apart from a lower binding of beta-subunit immunoactivity to ricin 120. No clinically useful diagnostic measures to distinguish hCG from normal and EPs were found.<h4>Conclusions</h4>No obvious differences were found in the isoforms of hCG between the two types of pregnancy using these methods.
Keywords: Trophoblasts; Blood; Urine; Humans; Pregnancy, Ectopic; Chorionic Gonadotropin; Lectins; Immunoassay; Postoperative Period; Chromatography; Retrospective Studies; Pregnancy; Isomerism; Reference Values; Female
RMID: 0030005272
DOI: 10.1016/S0015-0282(16)57846-7
Appears in Collections:Obstetrics and Gynaecology publications

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