Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/82236
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Type: Journal article
Title: Tap63 regulates oncogenic miR-155 to mediate migration and tumour growth
Author: Mattiske, S.
Ho, K.
Noll, J.
Neilsen, P.
Callen, D.
Suetani, R.
Citation: Oncotarget, 2013; 4(11):1894-1903
Publisher: Impact Journals LLC
Issue Date: 2013
ISSN: 1949-2553
1949-2553
Statement of
Responsibility: 
Sam Mattiske, Kristen Ho, Jacqueline E. Noll, Paul M. Neilsen, David F. Callen and Rachel J. Suetani
Abstract: miR-155 is an oncogenic microRNA which is upregulated in many solid cancers. The targets of miR-155 are well established , with over 100 confirmed mRNA targets. However, the regulation of miR-155 and the basis of its upregulation in cancer is not well understood. We have previously shown that miR-155 is regulated by p63, and here we investigate the role of the major p63 isoforms TAp63 and ΔNp63 in this regulation. When the TAp63 isoform was knocked down, or exogenously overexpressed, miR-155 levels were elevated in response to TAp63 knockdown or reduced in response to TAp63 overexpression. The ΔNp63 isoform is shown to directly bind to the p63 response element on the miR-155 host gene, and this binding is enriched when TAp63 is knocked down. This could indicate that TAp63 prevents ΔNp63 from binding to the miR-155 host gene. The knockdown of TAp63, and the subsequent elevation of miR-155, enhances migration and tumour growth similar to that seen when directly overexpressing miR-155. The migratory phenotype is abrogated when miR-155 is inhibited, indicating that miR-155 is responsible for the phenotypic effect of TAp63 knockdown.
Keywords: miR-155; TAp63; ΔNp63; cancer; tumorigenesis; migration
Rights: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020134382
DOI: 10.18632/oncotarget.1228
Published version: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=1228
Appears in Collections:Medicine publications

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