Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8225
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Type: Journal article
Title: Hepatocyte growth factor in human semen and its association with semen parameters
Author: Wiltshire, E.
Flaherty, S.
Couper, R.
Citation: Human Reproduction, 2000; 15(7):1525-1528
Publisher: Oxford Univ Press
Issue Date: 2000
ISSN: 0268-1161
1460-2350
Statement of
Responsibility: 
Esko J. Wiltshire, Sean P. Flaherty and Richard T.L. Couper
Abstract: Hepatocyte growth factor (HGF) is a structurally unique growth factor with potent motogenic (motility inducing) effects. Studies in the murine male genital tract have suggested important associations between HGF and the acquisition of sperm motility during epididymal maturation. The aim of this study was, therefore, to determine the concentration of HGF in human semen and assess its correlation, if any, with sperm motility and other semen parameters. Semen samples were collected by masturbation and analysed using standard procedures. HGF concentrations were measured in duplicate using an enzyme-linked immunoassay technique. Total protein estimations were also made in a subset of samples. The 95 subjects were divided into three groups for analysis: normozoospermic, subnormal semen and azoospermic. HGF was detected in all samples (median 0.456, 25th centile 0.388, 75th centile 0.556 ng/ml). No significant correlations were found between semen HGF concentrations and sperm concentration, motility, total sperm count or total motile count. There were no significant differences in mean HGF concentrations between the three subgroups. In conclusion HGF is present in human semen in significant quantities. The data do not suggest HGF concentrations are correlated with parameters of sperm motility.
Keywords: Semen; Humans; Oligospermia; Hepatocyte Growth Factor; Sperm Count; Sperm Motility; Osmolar Concentration; Reference Values; Adult; Middle Aged; Male
RMID: 0001000537
DOI: 10.1093/humrep/15.7.1525
Appears in Collections:Obstetrics and Gynaecology publications

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