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dc.contributor.authorBersten, D.en
dc.contributor.authorSullivan, A.en
dc.contributor.authorPeet, D.en
dc.contributor.authorWhitelaw, M.en
dc.identifier.citationNature Reviews. Cancer, 2013; 13(12):827-841en
dc.description.abstractMammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains. PAS domains form a generic three-dimensional fold, which commonly contains an internal cavity capable of small-molecule binding and outer surfaces adept at protein–protein interactions. These proteins are important in several pro-tumour and antitumour pathways and their activities can be modulated by both natural metabolites and oncometabolites. Recently determined structures and successful small-moleculescreening programmes are now providing new opportunities to discover selective agonists and antagonists directed against this multitasking family of transcription factors.en
dc.description.statementofresponsibilityDavid C. Bersten, Adrienne E. Sullivan, Daniel J. Peet & Murray L. Whitelawen
dc.publisherNature Publishing Groupen
dc.rights© 2013 Macmillan Publishers Limited. All rights reserveden
dc.subjectAnimals; Humans; Neoplasms; Cell Hypoxia; Gene Expression Regulation, Neoplastic; Circadian Rhythm; Basic Helix-Loop-Helix Transcription Factors; CLOCK Proteins; Circadian Clocksen
dc.titleBHLH-PAS proteins in canceren
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
Appears in Collections:Molecular and Biomedical Science publications

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