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https://hdl.handle.net/2440/82651
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Type: | Journal article |
Title: | BHLH-PAS proteins in cancer |
Author: | Bersten, D. Sullivan, A. Peet, D. Whitelaw, M. |
Citation: | Nature Reviews Cancer, 2013; 13(12):827-841 |
Publisher: | Nature Publishing Group |
Issue Date: | 2013 |
ISSN: | 1474-175X 1474-1768 |
Statement of Responsibility: | David C. Bersten, Adrienne E. Sullivan, Daniel J. Peet & Murray L. Whitelaw |
Abstract: | Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains. PAS domains form a generic three-dimensional fold, which commonly contains an internal cavity capable of small-molecule binding and outer surfaces adept at protein–protein interactions. These proteins are important in several pro-tumour and antitumour pathways and their activities can be modulated by both natural metabolites and oncometabolites. Recently determined structures and successful small-moleculescreening programmes are now providing new opportunities to discover selective agonists and antagonists directed against this multitasking family of transcription factors. |
Keywords: | Animals Humans Neoplasms Cell Hypoxia Gene Expression Regulation, Neoplastic Circadian Rhythm Basic Helix-Loop-Helix Transcription Factors CLOCK Proteins Circadian Clocks |
Rights: | © 2013 Macmillan Publishers Limited. All rights reserved |
DOI: | 10.1038/nrc3621 |
Published version: | http://dx.doi.org/10.1038/nrc3621 |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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