Gut motility and enteroendocrine secretion
Date
2013
Authors
Wu, T.
Rayner, C.
Young, R.
Horowitz, M.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Current Opinion in Pharmacology, 2013; 13(6):928-934
Statement of Responsibility
Tongzhi Wu, Christopher K Rayner, Richard L Young, Michael Horowitz
Conference Name
Abstract
The motility of the gastrointestinal (GI) tract is modulated by complex neural and hormonal networks; the latter include gut peptides released from enteroendocrine cells during both the interdigestive and postprandial periods. Conversely, it is increasingly recognised that GI motility is an important determinant of gut hormone secretion, in that the transit of luminal contents influences the degree of nutrient stimulation of enteroendocrine cells in different gut regions, as well as the overall length of gut exposed to nutrient. Of particular interest is the relationship between gallbladder emptying and enteroendocrine secretion. The inter-relationships between GI motility and enteroendocrine secretion are central to blood glucose homeostasis, where an understanding is fundamental to the development of novel strategies for the management of diabetes mellitus.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2013 Elsevier Ltd. All rights reserved.