Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/82679
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Type: Journal article
Title: Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype
Author: Appleton, S.
Seaborn, C.
Visvanathan, R.
Hill, C.
Gill, T.
Taylor, A.
Adams, R.
Citation: Diabetes Care, 2013; 36(8):2388-2394
Publisher: Amer Diabetes Assoc
Issue Date: 2013
ISSN: 0149-5992
1935-5548
Statement of
Responsibility: 
Sarah L. Appleton, Christopher J. Seaborn, Renuka Visvanathan, Catherine L. Hill, Tiffany K. Gill, Anne W. Taylor, Robert J. Adams on behalf of the North West Adelaide Health Study Team
Abstract: OBJECTIVE To determine the correlates of the “metabolically healthy obese” (MHO) phenotype and the longitudinal risks of diabetes and cardiovascular disease (CVD)/stroke associated with this phenotype. RESEARCH DESIGN AND METHODS The North West Adelaide Health Study is a prospective cohort study of 4,056 randomly selected adults aged ≥18 years. Participants free of CVD/stroke and not underweight (n = 3,743) were stratified by BMI categories and metabolic risk, defined as having two or more International Diabetes Federation metabolic syndrome criteria, excluding waist circumference. RESULTS Correlates of the MHO (n = 454 [12.1%]) included smoking, socioeconomic disadvantage, and physical inactivity. Compared with metabolically healthy normal-weight subjects (n = 1,172 [31.3%]), the MHO were more likely to develop metabolic risk (15.5 vs. 33.1%, P < 0.001) and incident diabetes (odds ratio 2.09 [95% CI 0.87–5.03]) but not CVD/stroke (1.16 [0.58–2.29]) during 5.5–10.3 years of follow-up. These risks were not seen in MHO subjects maintaining metabolic health (n = 188 [67%]). Sustained metabolic health in obese participants was associated with age ≤40 years and lower waist circumference. Compared with the metabolically at-risk obese, MHO women demonstrated a significantly higher (mean [SE]) percentage of leg fat (49.9 [0.5] vs. 53.2 [0.7]) and lower waist circumference (104 [0.6] vs. 101 cm [0.8]), despite no significant differences in overall adiposity. CONCLUSIONS “Healthy” obesity was a transient state for one-third of subjects. Persistence of a MHO phenotype, which was associated with favorable outcomes, was related to younger age and a more peripheral fat distribution. The MHO phenotype may be sustained by promoting lower waist circumferences.
Keywords: North West Adelaide Health Study Team; Humans; Cardiovascular Diseases; Diabetes Mellitus; Obesity; Risk; Cohort Studies; Follow-Up Studies; Motor Activity; Body Composition; Phenotype; Adult; Middle Aged; Female; Male; Overweight; Waist Circumference
Rights: © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
RMID: 0020133582
DOI: 10.2337/dc12-1971
Appears in Collections:Medicine publications

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