Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/82724
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases) |
Author: | Buxade, M. Parra-Palau, J. Proud, C. |
Citation: | Frontiers in Bioscience, 2008; 13(14):5359-5374 |
Publisher: | Frontiers in Bioscience Inc |
Issue Date: | 2008 |
ISSN: | 1093-9946 2768-6698 |
Statement of Responsibility: | Maria Buxade, Josep L. Parra-Palau, Christopher G. Proud |
Abstract: | The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP kinase-binding region. The N-termini of all forms contain a polybasic region which binds importin a and the translation factor scaffold protein eukaryotic initiation factor (eIF) 4G. The catalytic domains of Mnk1a/b and Mnk2a/b share three unusual features: two short inserts and a DFD feature where other kinases have DFG. Mnk isoforms differ markedly in their activity and regulation, and in subcellular localization. The best-characterised Mnk substrate is eIF4E. The cellular role of eIF4E phosphorylation remains unclear: it may promote export of certain mRNAs from the nucleus. Other Mnk substrates bind to AU-rich elements that modulate the stability/translation of specific mRNAs. Mnks may also control production of inflammatory mediators and signaling from tyrosine kinase receptors, as well as cell proliferation or survival. |
Keywords: | Mnk MAP Kinase Initiation Factor mRNA Translation Cytokine Apoptosis Review |
Rights: | © Frontiers in Bioscience |
DOI: | 10.2741/3086 |
Published version: | http://dx.doi.org/10.2741/3086 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.