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|Title:||The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)|
|Citation:||Frontiers in Bioscience, 2008; 13(14):5359-5374|
|Publisher:||Frontiers in Bioscience Inc|
|Maria Buxade, Josep L. Parra-Palau, Christopher G. Proud|
|Abstract:||The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP kinase-binding region. The N-termini of all forms contain a polybasic region which binds importin a and the translation factor scaffold protein eukaryotic initiation factor (eIF) 4G. The catalytic domains of Mnk1a/b and Mnk2a/b share three unusual features: two short inserts and a DFD feature where other kinases have DFG. Mnk isoforms differ markedly in their activity and regulation, and in subcellular localization. The best-characterised Mnk substrate is eIF4E. The cellular role of eIF4E phosphorylation remains unclear: it may promote export of certain mRNAs from the nucleus. Other Mnk substrates bind to AU-rich elements that modulate the stability/translation of specific mRNAs. Mnks may also control production of inflammatory mediators and signaling from tyrosine kinase receptors, as well as cell proliferation or survival.|
|Keywords:||Mnk; MAP Kinase; Initiation Factor; mRNA Translation; Cytokine; Apoptosis; Review|
|Rights:||© Frontiers in Bioscience|
|Appears in Collections:||Molecular and Biomedical Science publications|
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