Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/82767
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease |
| Author: | Jones, S. Neilsen, P. Siew, L. Callen, D. Goldfarb, N. Dunn, B. Abell, A. |
| Citation: | ChemMedChem: chemistry enabling drug discovery, 2013; 8(12):1918-1921 |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| Issue Date: | 2013 |
| ISSN: | 1860-7179 1860-7187 |
| Statement of Responsibility: | Seth A. Jones, Paul M. Neilsen, Limei Siew, David F. Callen, Nathan E. Goldfarb, Ben M. Dunn, and Andrew D. Abell |
| Abstract: | Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2 , and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease. |
| Keywords: | inhibitors peptidomimetics proteases templates β-strands |
| Description: | Article first published online: 15 OCT 2013 |
| Rights: | © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
| DOI: | 10.1002/cmdc.201300387 |
| Published version: | http://dx.doi.org/10.1002/cmdc.201300387 |
| Appears in Collections: | Aurora harvest 2 Chemistry and Physics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.