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Type: Journal article
Title: A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease
Author: Jones, S.
Neilsen, P.
Siew, L.
Callen, D.
Goldfarb, N.
Dunn, B.
Abell, A.
Citation: ChemMedChem: chemistry enabling drug discovery, 2013; 8(12):1918-1921
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
Issue Date: 2013
ISSN: 1860-7179
Statement of
Seth A. Jones, Paul M. Neilsen, Limei Siew, David F. Callen, Nathan E. Goldfarb, Ben M. Dunn, and Andrew D. Abell
Abstract: Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2 , and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.
Keywords: inhibitors
Description: Article first published online: 15 OCT 2013
Rights: © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/cmdc.201300387
Appears in Collections:Aurora harvest 2
Chemistry and Physics publications

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