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https://hdl.handle.net/2440/83310
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Type: | Journal article |
Title: | Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus |
Author: | Van Der Laan, L. Hudson, M. McPherson, S. Zondervan, P. Thomas, R. Kwekkeboom, J. Lindsay, A. Burt, A. Kazemier, G. Tilanus, H. Bassendine, M. Metselaar, H. |
Citation: | Transplantation Proceedings, 2010; 42(10):4573-4577 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2010 |
ISSN: | 0041-1345 1873-2623 |
Statement of Responsibility: | L.J.W. van der Laan, M. Hudson, S. McPherson, P.E. Zondervan, R.C. Thomas, J. Kwekkeboom, A.S. Lindsay, A.D. Burt, G. Kazemier, H.W. Tilanus, M.F. Bassendine, H.J. Metselaar |
Abstract: | A 2-center retrospective analysis was performed in 60 patients undergoing liver transplantation for hepatitis C virus (HCV)–related disease (cyclosporine in 20, tacrolimus in 40). Mean (±SEM) follow-up was 23.6 ± 22.5 and 22.3 ± 13.7 months in patients receiving cyclosporine or tacrolimus, respectively. Clinically indicated biopsies were performed in 15/20 cyclosporine patients (75%) and 22/40 tacrolimus patients (55%; P = .17). The Ishak fibrosis score was significantly lower in cyclosporine-treated patients versus tacrolimus-treated patients (mean 1.7 ± 0.4 vs 3.1 ± 0.4; P = .023), as was percentage of fibrosis grade Ishak ≥4 (7% vs 41%; P = .028). The mean time to moderate fibrosis (Ishak score ≥3) was 38.2 ± 15.1 months in cyclosporine patients (4/15) and 23.5 ± 12.6 months in tacrolimus patients (14/22); the difference was not statistically significant (P = .09). This retrospective study suggests that cyclosporine-based immunosuppression is associated with less severe hepatic fibrosis in HCV-positive liver transplant recipients compared with tacrolimus-based regimens, but a larger prospective comparative trial is necessary to confirm these findings. |
Keywords: | Humans Hepatitis C Liver Cirrhosis Disease Progression Tacrolimus Cyclosporine Immunosuppressive Agents Liver Transplantation Retrospective Studies Middle Aged Female Male |
Rights: | © 2010 by Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.transproceed.2010.10.013 |
Published version: | http://dx.doi.org/10.1016/j.transproceed.2010.10.013 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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