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Type: Journal article
Title: A genome-wide association scan for asthma in a general Australian population
Author: Hui, J.
Oka, A.
James, A.
Palmer, L.
Musk, A.
Beilby, J.
Inoko, H.
Citation: Human Genetics, 2008; 123(3):297-306
Publisher: Springer
Issue Date: 2008
ISSN: 0340-6717
Statement of
J. Hui, A. Oka, A. James, L. J. Palmer, A. W. Musk, J. Beilby, H. Inoko
Abstract: To date, almost every chromosome has been implicated in genetic susceptibility to asthma to some degree. When compared with single nucleotide polymorphism, microsatellite markers exhibit high levels of heterozygosity and therefore provide higher statistical power in association. The objective of this study was to perform a genome-wide association study using 23,465 in-house microsatellite markers to detect asthma susceptibility regions in the Busselton population. In this study, three separate pooled DNA screenings yielded 18 markers with significantly different estimated frequencies in the three separate "case and control" pools: each pool consisting of 60 males and 60 females. These markers were evaluated by individual typing in 360 cases and 360 controls. Two markers showed significant differences between cases and controls (P = 0.001 and P = 0.003). Regions surrounding the two markers were subjected to high-density association mapping with a total of 14 additional markers. We were able to confirm and fine map the association in these two regions by typing 14 additional microsatellite markers (1805A09 (D18S0325i), P = 0.002; 1806D05 (D18S0181i), P = 0.001). Each region contains a predicted gene that showed strong associations with asthma. Further studies are underway to characterize the novel candidate asthma susceptibility genes identified in this genome-wide study.
Keywords: Chromosomes, Human, Pair 18
Genetic Predisposition to Disease
DNA Primers
Health Surveys
Case-Control Studies
Follow-Up Studies
Cross-Sectional Studies
Chromosome Mapping
Microsatellite Repeats
Polymorphism, Single Nucleotide
Genome, Human
Middle Aged
Genetic Linkage
Rights: © Springer-Verlag 2008
DOI: 10.1007/s00439-008-0477-9
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