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https://hdl.handle.net/2440/83485
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dc.contributor.author | Smallwood, L. | - |
dc.contributor.author | Allcock, R. | - |
dc.contributor.author | van Bockxmeer, F. | - |
dc.contributor.author | Warrington, N. | - |
dc.contributor.author | Palmer, L. | - |
dc.contributor.author | Iacopetta, B. | - |
dc.contributor.author | Golledge, J. | - |
dc.contributor.author | Norman, P. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | British Journal of Surgery, 2008; 95(10):1239-1244 | - |
dc.identifier.issn | 0007-1323 | - |
dc.identifier.issn | 1365-2168 | - |
dc.identifier.uri | http://hdl.handle.net/2440/83485 | - |
dc.description.abstract | <h4>Background</h4>Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP-9 gene and AAA.<h4>Methods</h4>The -1562C > T and -1811A > T variants of the MMP-9 gene were genotyped in 678 men with an AAA (at least 30 mm in diameter) and 659 control subjects (aortic diameter 19-22 mm) recruited from a population-based trial of screening for AAA. Levels of MMP-9 were measured in a random subset of 300 cases and 84 controls. The association between genetic variants (including haplotypes) and AAA was assessed by multivariable logistic regression.<h4>Results</h4>There was no association between the MMP-9-1562C > T (odds ratio (OR) 0.70 (95 per cent confidence interval (c.i.) 0.27 to 1.82)) or -1811A > T (OR 0.71 (95 per cent c.i. 0.28 to 1.85)) genotypes, or the most common haplotype (OR 0.81 (95 per cent c.i. 0.62 to 1.05)) and AAA. The serum MMP-9 concentration was higher in cases than controls, and in minor allele carriers in cases and controls, although the differences were not statistically significant.<h4>Conclusion</h4>In this study, the genetic tendency to higher levels of circulating MMP-9 was not associated with AAA. | - |
dc.description.statementofresponsibility | L. Smallwood, R. Allcock, F. van Bockxmeer, N. Warrington, L. J. Palmer, B. Iacopetta, J. Golledge and P. E. Norman | - |
dc.language.iso | en | - |
dc.publisher | John Wiley & Sons Ltd | - |
dc.rights | Copyright © 2008 British Journal of Surgery Society Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1002/bjs.6345 | - |
dc.subject | Humans | - |
dc.subject | Aortic Aneurysm, Abdominal | - |
dc.subject | Case-Control Studies | - |
dc.subject | Genotype | - |
dc.subject | Polymorphism, Genetic | - |
dc.subject | Aged | - |
dc.subject | Aged, 80 and over | - |
dc.subject | Male | - |
dc.subject | Matrix Metalloproteinase 9 | - |
dc.title | Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/bjs.6345 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Palmer, L. [0000-0002-1628-3055] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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