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Type: Journal article
Title: Serotonin depletion decreases light induced c-fos in the rat suprachiasmatic nucleus
Author: Moyer, R.
Kennaway, D.
Citation: NeuroReport, 2000; 11(5):1021-1024
Publisher: Lippincott Williams & Wilkins
Issue Date: 2000
ISSN: 0959-4965
Statement of
Robert W. Moyer and David J. Kennaway
Abstract: The suprachiasmatic nucleus (SCN) is the locus of the biological clock in mammals. Daily light cycles entrain the endogenous circadian rhythms in mammals through direct and indirect neural pathways from the retinae to the suprachiasmatic nucleus. We have studied the effect of serotonin depletion on the photic induction of the early response gene c-fas in the SCN of rats. Serotonin depletion, verified by immunohistochemistry, produced a significant decrease (42%) in the number of c-FOS positive cells in the ventrolateral portion of the SCN. These results support the involvement of serotonin as a mediator of photic information to the SCN through the retinal projection to the dorsal raphe nucleus.
Keywords: c-FOS
Circadian rhythm
Suprachiasmatic nucleus
Rights: © 2000 Lippincott Williams & Wilkins
DOI: 10.1097/00001756-200004070-00025
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