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https://hdl.handle.net/2440/8415
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Type: | Journal article |
Title: | Serotonin depletion decreases light induced c-fos in the rat suprachiasmatic nucleus |
Author: | Moyer, R. Kennaway, D. |
Citation: | NeuroReport, 2000; 11(5):1021-1024 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2000 |
ISSN: | 0959-4965 1473-558X |
Statement of Responsibility: | Robert W. Moyer and David J. Kennaway |
Abstract: | The suprachiasmatic nucleus (SCN) is the locus of the biological clock in mammals. Daily light cycles entrain the endogenous circadian rhythms in mammals through direct and indirect neural pathways from the retinae to the suprachiasmatic nucleus. We have studied the effect of serotonin depletion on the photic induction of the early response gene c-fas in the SCN of rats. Serotonin depletion, verified by immunohistochemistry, produced a significant decrease (42%) in the number of c-FOS positive cells in the ventrolateral portion of the SCN. These results support the involvement of serotonin as a mediator of photic information to the SCN through the retinal projection to the dorsal raphe nucleus. |
Keywords: | c-FOS Circadian rhythm Immunohistochemistry Rat Serotonin Suprachiasmatic nucleus |
Rights: | © 2000 Lippincott Williams & Wilkins |
DOI: | 10.1097/00001756-200004070-00025 |
Published version: | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200004070-00025&LSLINK=80&D=ovft |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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