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https://hdl.handle.net/2440/8426
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dc.contributor.author | Tsalsaris, V. | - |
dc.contributor.author | Papatsonis, D. | - |
dc.contributor.author | Goffinet, F. | - |
dc.contributor.author | Dekker, G. | - |
dc.contributor.author | Carbonne, B. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Obstetrics and Gynecology, 2001; 97(5, Part 2):840-847 | - |
dc.identifier.issn | 0029-7844 | - |
dc.identifier.issn | 1873-233X | - |
dc.identifier.uri | http://hdl.handle.net/2440/8426 | - |
dc.description.abstract | Objective: To clarify the relative efficacy of nifedipine and beta-agonists for tocolysis. Data Sources: The literature was searched in the following databases: MEDLINE 1965–1998, Embase 1988–1998, Current Contents 1997–1998, and the Cochrane Database for 1998. We also sought unpublished trials and abstracts submitted to major international congresses. Search terms were: “tocolysis,” “nifedipine,” “calcium channel blocker,” “ritodrine,” “terbutaline,” and “salbutamol.” Methods of Study Selection: Randomized controlled trials comparing tocolysis with nifedipine and beta-adrenergic agonists during preterm labor were reviewed. In cases with postrandomization exclusions, authors were contacted to obtain intent-to-treat results and to avoid analytical bias. We identified 11 published and two unpublished randomized trials. Tabulation, Integration, and Results: Data were extracted by two reviewers and analyzed by a blinded biostatistician with RevMan 3.1 software from the Cochrane Collaboration. We analyzed nine relevant randomized controlled trials that included 679 patients. Meta-analysis showed that nifedipine was more effective than the beta-agonists in delaying delivery at least 48 hours [odds ratio (OR) 1.52, 95% confidence interval (CI) 1.03, 2.24], or over 34 weeks (OR 1.87, 95% CI 1.11, 3.15). The agents did not differ as to the incidence of deliveries after 37 weeks (OR 1.29, 95% CI 0.85, 1.96) or the neonatal mortality rate (OR 1.51, 95% CI 0.63, 3.65). Treatment with nifedipine was interrupted significantly less often because of side effects (OR 0.12, 95% CI 0.05, 0.29) and led to better neonatal outcomes (fewer infants with respiratory distress syndrome: OR 0.57, 95% CI 0.37, 0.89) or transferred to neonatal intensive care units (OR 0.65, 95% CI 0.43, 0.97). Conclusion: With respect to neonatal outcome, nifedipine appears to be more effective than beta-agonists for tocolysis and should be considered for use as a first-line tocolytic agent. | - |
dc.description.uri | http://www.ionchannels.org/showabstract.php?pmid=11336775 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Inc | - |
dc.rights | © 2001 The American College of Obstetricians and Gynecologists | - |
dc.source.uri | http://dx.doi.org/10.1016/s0029-7844(00)01212-6 | - |
dc.subject | Humans | - |
dc.subject | Nifedipine | - |
dc.subject | Tocolytic Agents | - |
dc.subject | Adrenergic beta-Agonists | - |
dc.subject | Tocolysis | - |
dc.subject | Pregnancy | - |
dc.subject | Female | - |
dc.subject | Obstetric Labor, Premature | - |
dc.subject | Randomized Controlled Trials as Topic | - |
dc.title | Tocolysis with nifedipine or beta-adrenergic agonists: A meta-analysis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0029-7844(00)01212-6 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Dekker, G. [0000-0002-7362-6683] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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