Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8443
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Type: Journal article
Title: Peripheral Heat Loss: A Predictor of the Hypothermic Response to Melatonin Administration in Young and Older Women
Author: Gilbert, S.
van den Heuvel, C.
Kennaway, D.
Dawson, D.
Citation: Physiology and Behavior, 1999; 66(2):365-370
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Issue Date: 1999
ISSN: 0031-9384
1873-507X
Abstract: Core hypothermia following daytime melatonin administration typically displays significant interindividual variability. As this hypothermia has been associated with significant increases in skin temperature, the mechanism by which melatonin decreases core temperature may involve increasing peripheral heat loss. If so, the interindividual variability in this effect may reflect concomitant interindividual variability in heat loss capacity at the distal periphery. For six younger (mean +/- SEM: 23.4 +/- 0.3 years) and 10 older women (mean +/- SEM: 65.6 +/- 0.7 years), the maximum decrease in core body temperature following a 5-mg (p.o.) dose of melatonin was correlated with the capacity to lose heat. This was determined by the maximum increase in contralateral hand temperature following a mild positive thermal challenge (PTC). The regression analysis yielded a significant (p < 0.01) correlation of 0.80, suggesting that the individual magnitude of hypothermia following melatonin administration may reflect the capacity of an individual to dissipate heat at the distal periphery.
Keywords: Humans
Melatonin
Antioxidants
Body Temperature
Regression Analysis
Body Temperature Regulation
Aging
Adult
Aged
Middle Aged
Female
Hot Temperature
DOI: 10.1016/S0031-9384(98)00309-6
Appears in Collections:Aurora harvest 4
Obstetrics and Gynaecology publications

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