Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/84476
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: The capture and stabilization of curcumin using hydrophobically modified polyacrylate aggregates and hydrogels
Author: Harada, T.
Pham, D.-.T.
Lincoln, S.
Kee, T.
Citation: The Journal of Physical Chemistry B, 2014; 118(31):9515-9523
Publisher: ACS Publications
Issue Date: 2014
ISSN: 1520-6106
1520-5207
Statement of
Responsibility: 
Takaaki Harada, Duc-Truc Pham, Stephen F. Lincoln and Tak W. Kee
Abstract: Hydrophobically modified polyacrylates are shown to suppress the degradation of the medicinal pigment curcumin under physiological conditions. In aqueous solution, the 3% octadecyl randomly substituted polyacrylate, PAAC18, forms micelle-like aggregates at a concentration of <1 wt % and a hydrogel at >1 wt %. Under both conditions, PAAC18 shows a remarkable ability to suppress the degradation of curcumin at pH 7.4 and 37 °C such that its degradation half-life is increased by 1600-2000-fold. The suppression of degradation is attributed to hydrophobic interactions between curcumin and the octadecyl substituents of PAAC18 within the micelle-like aggregates and the hydrogel, as indicated by 2D NOESY 1H NMR spectroscopy. UV- visible absorption titration results are consistent with the interaction of curcumin with five octadecyl substituents on average, which appears to substantially exclude water and greatly decrease the curcumin degradation rate. Dynamic light scattering and zeta potential measurements show the average hydrodynamic diameters of the PAAC18 aggregates to be 0.86-1.15 micrometers with a negative surface charge. In contrast to the octadecyl substitution, the 3% dodecyl randomly substituted polyacrylate, PAAC12, shows a negligible effect on slowing the degradation of curcumin, consistent with the dodecyl substituents being insufficiently long to capture curcumin in a adequately hydrophobic environment. These observations indicate the potential for PAAC18 to act as a model drug delivery system.
Keywords: Water; Curcumin; Polymers; Hydrogels; Solutions; Drug Delivery Systems; Temperature; Molecular Structure; Micelles; Hydrogen-Ion Concentration; Scattering, Radiation; Hydrophobic and Hydrophilic Interactions; Proton Magnetic Resonance Spectroscopy
Rights: © 2014 American Chemical Society
RMID: 0030006829
DOI: 10.1021/jp5060205
Grant ID: http://purl.org/au-research/grants/arc/DP0878100
http://purl.org/au-research/grants/arc/LE0989747
http://purl.org/au-research/grants/arc/DP110103177
Appears in Collections:Chemistry publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.