Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8529
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Type: Journal article
Title: Programming of the fetal suprachiasmatic nucleus and subsequent adult rhythmicity
Author: Kennaway, D.
Citation: Trends in Endocrinology and Metabolism, 2002; 13(9):398-402
Publisher: Elsevier Science London
Issue Date: 2002
ISSN: 1043-2760
1879-3061
Statement of
Responsibility: 
David J. Kennaway
Abstract: The suprachiasmatic nucleus (SCN) is the site of the generation and entrainment of circadian rhythms. Similar to other structures, it develops throughout gestation but is still immature for some time after. This suggests that the SCN could be vulnerable to maternal influences, such as poor nutrition, stress and drugs, all of which can affect neuronal development. Evidence is accumulating that suggests that this is the case, with body size at birth influencing melatonin production in adult humans and maternal malnutrition, and stress affecting sleep in rodents. Interestingly, the maternal environment affects the phase of rhythms and the response of the circadian timing system to light pulses. The nature of these changes in adult rhythmicity is similar to those commonly associated with depression in humans. Thus, abnormal fetal programming might predispose adults to depressive illness.
Keywords: circadian; melatonin; nutrition; stress; cocaine; dopamine; maternal environment; fetal environment; sleep
Description: Copyright © 2002 Elsevier Science Ltd. All rights reserved.
RMID: 0020021222
DOI: 10.1016/S1043-2760(02)00692-6
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/505783/description#description
Appears in Collections:Obstetrics and Gynaecology publications

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