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https://hdl.handle.net/2440/85458
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Type: | Journal article |
Title: | Cost-effectiveness analysis of cervical length measurement and fibronectin testing in women with threatened preterm labor |
Author: | van Baaren, G. Vis, J. Grobman, W. Bossuyt, P. Opmeer, B. Mol, B. |
Citation: | American Journal of Obstetrics and Gynecology, 2013; 209(5):436.e1-436.e8 |
Publisher: | Mosby |
Issue Date: | 2013 |
ISSN: | 0002-9378 1097-6868 |
Statement of Responsibility: | Gert-Jan van Baaren, Jolande Y. Vis, William A. Grobman, Patrick M. Bossuyt, Brent C. Opmeer, Ben W. Mol |
Abstract: | <h4>Objective</h4>The objective of the study was to evaluate the cost-effectiveness of risk stratification with cervical length (CL) measurement and/or fetal fibronectin (fFN) tests in women with threatened preterm labor between 24 and 34 weeks' gestation.<h4>Study design</h4>We performed a model-based cost-effectiveness analysis to evaluate 7 test-treatment strategies in women with threatened preterm labor from a health care system perspective. Estimates on disease prevalence, costs, and test accuracy were based on medical literature.<h4>Results</h4>We found that additional fFN testing in the case of a CL between 10 and 30 mm is cost saving without compromising neonatal health outcomes, compared with a treat-all strategy or single CL testing. Implementing this strategy could lead to an annual cost saving between €2.8 million and €14.4 million in The Netherlands, a country with about 180,000 deliveries annually.<h4>Conclusion</h4>In women with threatened preterm labor between 24 and 34 weeks of gestation, the most cost-effective test strategy uses a combination of CL and fFN testing. |
Keywords: | Cervical length; cost-effectiveness; economic evaluation; fibronectin; preterm labor |
Rights: | © 2013 Mosby, Inc. All rights reserved. |
DOI: | 10.1016/j.ajog.2013.06.029 |
Published version: | http://dx.doi.org/10.1016/j.ajog.2013.06.029 |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
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