Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8564
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Boeckxstaens, G. | - |
dc.contributor.author | Hirsch, D. | - |
dc.contributor.author | Fakhry, N. | - |
dc.contributor.author | Holloway, R. | - |
dc.contributor.author | D'Amato, M. | - |
dc.contributor.author | Tytgat, G. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | American Journal of Gastroenterology, 1998; 93(10):1823- | - |
dc.identifier.issn | 0002-9270 | - |
dc.identifier.issn | 1572-0241 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8564 | - |
dc.description.abstract | <h4>Objective</h4>Transient lower esophageal sphincter relaxations (TLESRs) are the main mechanism underlying gastroesophageal reflux. In the present study we evaluated the effect of loxiglumide, a specific cholecystokininA (CCKA)-receptor antagonist, on the occurrence of TLESRs evoked by gastric distension.<h4>Methods</h4>Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide (10 mg/kg/h) in a randomized double-blind order. Gastric distension was induced by inflation of 400 ml of air.<h4>Results</h4>Basal lower esophageal pressure (LESP) and swallow-induced relaxation were not affected by loxiglumide. Loxiglumide significantly reduced the number of TLESRs, from 11.5 (5.8-18.3) to 6.0 (3.3-14.3) during the total recording period of 1 h, and from 5.5 (4.25-7.5) to 2.0 (0.5-6.8) during the first 15 min. The number of common cavities was significantly decreased by loxiglumide, from 8.0 (4.0-20.0) to 5.0 (2.0-7.8). TLESRs represented the main mechanism (60% during placebo, 74% during loxiglumide) underlying common cavities, followed by swallow-induced relaxation.<h4>Conclusions</h4>Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter, suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs. | - |
dc.description.statementofresponsibility | G. E. Boeckxstaens, D. P. Hirsch, N. Fakhry, R. H. Holloway, M. D’Amato, and G. N. J. Tytgat, | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.source.uri | http://dx.doi.org/10.1016/s0002-9270(98)00408-0 | - |
dc.subject | Esophagogastric Junction | - |
dc.subject | Stomach | - |
dc.subject | Humans | - |
dc.subject | Gastroesophageal Reflux | - |
dc.subject | Hormone Antagonists | - |
dc.subject | Proglumide | - |
dc.subject | Receptors, Cholecystokinin | - |
dc.subject | Receptor, Cholecystokinin A | - |
dc.subject | Reflex | - |
dc.subject | Double-Blind Method | - |
dc.subject | Manometry | - |
dc.subject | Deglutition | - |
dc.subject | Peristalsis | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Involvement of cholecystokinin A receptors in transient lower esophageal sphincter relaxations triggered by gastric distension | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0002-9270(98)00408-0 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.