Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8564
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dc.contributor.authorBoeckxstaens, G.-
dc.contributor.authorHirsch, D.-
dc.contributor.authorFakhry, N.-
dc.contributor.authorHolloway, R.-
dc.contributor.authorD'Amato, M.-
dc.contributor.authorTytgat, G.-
dc.date.issued1998-
dc.identifier.citationAmerican Journal of Gastroenterology, 1998; 93(10):1823--
dc.identifier.issn0002-9270-
dc.identifier.issn1572-0241-
dc.identifier.urihttp://hdl.handle.net/2440/8564-
dc.description.abstract<h4>Objective</h4>Transient lower esophageal sphincter relaxations (TLESRs) are the main mechanism underlying gastroesophageal reflux. In the present study we evaluated the effect of loxiglumide, a specific cholecystokininA (CCKA)-receptor antagonist, on the occurrence of TLESRs evoked by gastric distension.<h4>Methods</h4>Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide (10 mg/kg/h) in a randomized double-blind order. Gastric distension was induced by inflation of 400 ml of air.<h4>Results</h4>Basal lower esophageal pressure (LESP) and swallow-induced relaxation were not affected by loxiglumide. Loxiglumide significantly reduced the number of TLESRs, from 11.5 (5.8-18.3) to 6.0 (3.3-14.3) during the total recording period of 1 h, and from 5.5 (4.25-7.5) to 2.0 (0.5-6.8) during the first 15 min. The number of common cavities was significantly decreased by loxiglumide, from 8.0 (4.0-20.0) to 5.0 (2.0-7.8). TLESRs represented the main mechanism (60% during placebo, 74% during loxiglumide) underlying common cavities, followed by swallow-induced relaxation.<h4>Conclusions</h4>Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter, suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs.-
dc.description.statementofresponsibilityG. E. Boeckxstaens, D. P. Hirsch, N. Fakhry, R. H. Holloway, M. D’Amato, and G. N. J. Tytgat,-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE INC-
dc.subjectEsophagogastric Junction-
dc.subjectStomach-
dc.subjectHumans-
dc.subjectGastroesophageal Reflux-
dc.subjectHormone Antagonists-
dc.subjectProglumide-
dc.subjectReceptors, Cholecystokinin-
dc.subjectReceptor, Cholecystokinin A-
dc.subjectReflex-
dc.subjectDouble-Blind Method-
dc.subjectManometry-
dc.subjectDeglutition-
dc.subjectPeristalsis-
dc.subjectAdult-
dc.subjectFemale-
dc.subjectMale-
dc.titleInvolvement of cholecystokinin A receptors in transient lower esophageal sphincter relaxations triggered by gastric distension-
dc.typeJournal article-
dc.identifier.doi10.1016/S0002-9270(98)00408-0-
pubs.publication-statusPublished-
Appears in Collections:Aurora harvest
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