Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8571
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Effect of short term starvation on gastric emptying in normal and obese subjects - Relationship to oral glucose tolerance
Author: Corvilain, B.
Abramowicz, M.
Fery, F.
Schoutens, A.
Verlinden, M.
Balasse, E.
Horowitz, M.
Citation: American Journal of Physiology, 1995; 269(4):G512-G517
Publisher: American Physiological Society
Issue Date: 1995
ISSN: 0193-1857
1522-1547
Statement of
Responsibility: 
B. Corvilain, M. Abramowicz, F. Fery, A. Schoutens, M. Verlinden, E. Balasse, and M. Horowitz
Abstract: To evaluate the effects of short-term starvation on gastric emptying in normal and obese subjects, the relationship between gastric emptying and oral glucose tolerance, and the mechanisms responsible for the delay in the systemic appearance of oral glucose observed after short-term fasting, we determined the effects of a 4-day fast on 1) gastric emptying and oral glucose tolerance in normal subjects and 2) gastric emptying in obese patients. Gastric emptying of 75 g glucose (320 ml) labeled with 99mTc colloid was measured in 12 healthy volunteers and 11 obese subjects after 12-h and 4-day fasts. In seven other obese subjects, the effect of a 4-day fast on gastric emptying of 320 ml normal saline was quantified. Gastric emptying of glucose was slower after the 4-day than after the overnight fast in both normal (P = 0.02) and obese (P < 0.001) subjects, with no difference between the two groups. In normal subjects, the rate of gastric emptying was related directly to the rise in plasma glucose at 30 min (r = 0.60; P < 0.05) but inversely to the plasma glucose at 180 min (r = -0.64; P < 0.02). In the obese subjects, gastric emptying of saline was not affected by fasting. These observations indicate that 1) gastric emptying of glucose is retarded by a 4-day fast, 2) the changes in gastric emptying reported in obesity may reflect different patterns of prior nutrient intake, and 3) delay in gastric emptying accounts for the slower systemic appearance of glucose after fasting.
Keywords: Humans; Starvation; Obesity; Hormones; Glucose; Blood Glucose; Glucose Tolerance Test; Gastric Emptying; Osmolar Concentration; Time Factors; Reference Values; Adult; Female; Male
RMID: 0030005137
DOI: 10.1152/ajpgi.1995.269.4.g512
Published version: http://ajpgi.physiology.org/cgi/reprint/269/4/G512
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.