Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Pneumococcal carriage and type-specific antibody: failure of a 14-valent vaccine to reduce carriage in healthy children|
|Citation:||American Journal of Diseases of Children, 1986; 140(11):1183-1185|
|Publisher:||American Medical Association|
|Robert M. Douglas, David Hansman, Helen B. Miles, James C. Paton|
|Abstract:||No consistent effect on nasal carriage rates of Streptococcus pneumoniae belonging to vaccine types was observed during a randomized, controlled trial of a 14-valent pneumococcal vaccine, which included 1273 Australian children aged 6 to 54 months. Nasal carriage of S pneumoniae was associated with a significantly elevated homotypic serum antibody concentration for types 18C, 19F, and 23F, but not for types 6A and 14 (these five types are the most important causes of pneumococcal infections in children). Upper respiratory tract carriage seems to play an important role in natural acquisition of antibody to some but not all pneumococcal serotypes. These findings help to explain why pneumococcal vaccine fails to protect young children from acute otitis media.|
|Keywords:||Nose; Humans; Streptococcus pneumoniae; Bacterial Vaccines; Pneumococcal Vaccines; Antibodies, Bacterial; Serotyping; Double-Blind Method; Random Allocation; Child, Preschool; Infant; Clinical Trials as Topic|
|Rights:||Copyright status unknown|
|Appears in Collections:||Molecular and Biomedical Science publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.