Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/85737
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Type: Journal article
Title: Pneumococcal carriage and type-specific antibody: failure of a 14-valent vaccine to reduce carriage in healthy children
Author: Douglas, R.
Hansman, D.
Miles, H.
Paton, J.
Citation: American Journal of Diseases of Children, 1986; 140(11):1183-1185
Publisher: American Medical Association
Issue Date: 1986
ISSN: 0002-922X
2374-3018
Statement of
Responsibility: 
Robert M. Douglas, David Hansman, Helen B. Miles, James C. Paton
Abstract: No consistent effect on nasal carriage rates of Streptococcus pneumoniae belonging to vaccine types was observed during a randomized, controlled trial of a 14-valent pneumococcal vaccine, which included 1273 Australian children aged 6 to 54 months. Nasal carriage of S pneumoniae was associated with a significantly elevated homotypic serum antibody concentration for types 18C, 19F, and 23F, but not for types 6A and 14 (these five types are the most important causes of pneumococcal infections in children). Upper respiratory tract carriage seems to play an important role in natural acquisition of antibody to some but not all pneumococcal serotypes. These findings help to explain why pneumococcal vaccine fails to protect young children from acute otitis media.
Keywords: Nose; Humans; Streptococcus pneumoniae; Bacterial Vaccines; Pneumococcal Vaccines; Antibodies, Bacterial; Serotyping; Double-Blind Method; Random Allocation; Child, Preschool; Infant; Clinical Trials as Topic
Rights: Copyright status unknown
RMID: 0030008951
DOI: 10.1001/archpedi.1986.02140250109044
Appears in Collections:Molecular and Biomedical Science publications

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