Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8589
Type: Journal article
Title: Hyperglycaemia affects proximal gastric motor and sensory function during small intestinal triglyceride infusion
Author: Hebbard, G.
Samsom, M.
Sun, W.
Dent, J.
Horowitz, M.
Citation: American Journal of Physiology. Gastrointestinal and Liver Physiology, 1996; 271(5):G814-G819
Publisher: American Physiological Society
Issue Date: 1996
ISSN: 0002-9513
Statement of
Responsibility: 
G. S. Hebbard, M. Samsom, W. M. Sun, J. Dent, and M. Horowitz
Abstract: Hyperglycemia slows gastric emptying in normal individuals and patients with diabetes mellitus and may affect both somatic and visceral sensation. The effects of hyperglycemia on proximal gastric motility and sensation during intraduodenal infusion of a triglyceride emulsion were evaluated using a barostat in six normal subjects during euglycemia and hyperglycemia (approximately 15 mmol/l). Isobaric distension induced greater bag volumes during hyperglycemia compared with euglycemia at 3 (452 +/- 26 vs. 343 +/- 12 ml, P< 0.05) and 4 mmHg (600 +/- 55 vs. 497 +/- 50 ml, P < 0.05) above basal pressure. During isovolumetric distension, intrabag pressure was less during hyperglycemia at 500 (2.5 +/- 0.3 vs. 3.5 +/- 0.5 mmHg above basal pressure, P < 0.05) and 600 ml (3.0 +/- 0.4 vs. 4.5 +/- 0.5 mmHg above basal pressure, P < 0.05). Perception of nausea (P < 0.05) and fullness (P < 0.05) was increased during hyperglycemia compared with euglycemia. We conclude that hyperglycemia 1) reduces proximal gastric tone during intraduodenal triglyceride infusion, an effect that may contribute to delayed gastric emptying, and 2) increases the intensity of nausea and fullness during intraduodenal triglyceride infusion and proximal gastric distension, indicative of an effect on visceral sensation.
Rights: Copyright © 1996 the American Physiological Society
RMID: 0030005122
Published version: http://ajpgi.physiology.org/content/271/5/G814
Appears in Collections:Medicine publications

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