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https://hdl.handle.net/2440/86004
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Type: | Journal article |
Title: | Maternal thyroid hormone concentration during late gestation is associated with foetal position at birth |
Author: | Wijnen, H. Kooistra, L. Vader, H. Essed, G. Mol, B. Pop, V. |
Citation: | Clinical Endocrinology, 2009; 71(5):746-751 |
Publisher: | Blackwell |
Issue Date: | 2009 |
ISSN: | 0300-0664 1365-2265 |
Statement of Responsibility: | Hennie A. Wijnen, Libbe Kooistra, Huib L. Vader, Gerard G. Essed, Ben W. Mol and Victor J. Pop |
Abstract: | Objective: To evaluate whether there is an association between maternal thyroid hormone and foetal cephalic head position at term gestation. Context: Rotation and flexion of the head enables the foetus to negotiate the birth canal. Low-normal range thyroid hormone concentrations in euthyroid pregnant women constitute a risk of infant motor abnormality. We hypothesized that low normal maternal thyroid hormone levels are associated with increased risk of abnormal foetal position at delivery. Design: In 960 healthy Dutch women with term gestation and cephalic foetal presentation, thyroid parameters [foetal T4 (FT4), TSH and thyroid peroxidase antibody] were assessed at 36 weeks of gestation, and related to foetal head position (anterior cephalic vs. abnormal cephalic) and delivery mode (spontaneous vs. assisted delivery). Results: Women presenting in anterior position (n = 891) had significantly higher FT4 levels at 36 weeks of gestation than those with abnormal cephalic presentation (n = 69). There were no between-group differences for TSH. Regression analyses indicated that the risk of abnormal head position decreased as a function of increasing FT4 [single odds ratio (OR) = 0·87, 95% confidence intervals (CI) 0·77–0·98; multivariate OR = 0·88, 95% CI 0·72–0·99)]. A similar inverse relationship between maternal FT4 and risk of assisted delivery was obtained (OR = 0·86, 95% CI 0·79–0·95; OR = 0·91, 95% CI 0·84–0·98). Conclusion: The lower the maternal FT4 concentration at 36 weeks of gestation, the higher the risk of abnormal cephalic foetal presentation and assisted delivery. |
Keywords: | Humans Thyrotropin Thyroid Hormones Thyroxine Iodide Peroxidase Antibodies Pregnancy Labor Presentation Adult Female |
Rights: | © 2009 Blackwell Publishing Ltd |
DOI: | 10.1111/j.1365-2265.2009.03574.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2265.2009.03574.x |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
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