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Type: Journal article
Title: Immobilisation versus immediate mobilisation after intrauterine insemination: randomised controlled trial
Author: Custers, I.
Flierman, P.
Maas, P.
Cox, T.
Van Dessel, T.
Gerards, M.
Mochtar, M.
Janssen, C.
van der Veen, F.
Mol, B.
Citation: BMJ, 2009; 339(7729):1065-1067
Publisher: BMJ Publishing Group
Issue Date: 2009
ISSN: 1756-1833
Statement of
Inge M Custers, Paul A Flierman, Pettie Maas, Tessa Cox, Thierry J H M Van Dessel, Mariette H Gerards, Monique H Mochtar, Catharina A H Janssen, Fulco van der Veen and Ben Willem J Mol
Abstract: Objective To evaluate the effectiveness of 15 minutes of immobilisation versus immediate mobilisation after intrauterine insemination. Design Randomised controlled trial. Setting One academic teaching hospital and six non-academic teaching hospitals. Participants Women having intrauterine insemination for unexplained, cervical factor, or male subfertility. Interventions 15 minutes of immobilisation or immediate mobilisation after insemination. Main outcome measure Ongoing pregnancy per couple. Results 391 couples were randomised; 199 couples were allocated to 15 minutes of immobilisation after intrauterine insemination, and 192 couples were allocated to immediate mobilisation (control). The ongoing pregnancy rate per couple was significantly higher in the immobilisation group than in the control group: 27% (n=54) versus 18% (34); relative risk 1.5, 95% confidence interval 1.1 to 2.2 (crude difference in ongoing pregnancy rates: 9.4%, 1.2% to 17%). Live birth rates were 27% (53) in the immobilisation group and 17% (32) in the control group: relative risk 1.6, 1.1 to 2.4 (crude difference for live birth rates: 10%, 1.8% to 18%). In the immobilisation group, the ongoing pregnancy rates in the first, second, and third treatment cycles were 10%, 10%, and 7%. The corresponding rates in the mobilisation group were 7%, 5%, and 5%. Conclusion In treatment with intrauterine insemination, 15 minutes' immobilisation after insemination is an effective modification. Immobilisation for 15 minutes should be offered to all women treated with intrauterine insemination. Trial registration Current Controlled Trials ISRCTN53294431.
Keywords: Humans; Infertility, Male; Infertility, Female; Insemination, Artificial; Early Ambulation; Pregnancy Rate; Immobilization; Pregnancy; Supine Position; Time Factors; Adult; Middle Aged; Female; Male; Live Birth; Young Adult; Kaplan-Meier Estimate
Rights: Copyright status unknown
RMID: 0020136800
DOI: 10.1136/bmj.b4080
Appears in Collections:Paediatrics publications

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