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Type: Journal article
Title: The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
Author: Cross, M.
Smith, E.
Hoy, D.
Nolte, S.
Ackerman, I.
Fransen, M.
Bridgett, L.
Williams, S.
Guillemin, F.
Hill, C.
Laslett, L.
Jones, G.
Cicuttini, F.
Osborne, R.
Vos, T.
Buchbinder, R.
Woolf, A.
March, L.
Citation: Annals of the Rheumatic Diseases, 2014; 73(7):1323-1330
Publisher: BMJ Publishing Group
Issue Date: 2014
ISSN: 0003-4967
Statement of
Marita Cross, Emma Smith, Damian Hoy, Sandra Nolte, Ilana Ackerman, Marlene Fransen, Lisa Bridgett, Sean Williams, Francis Guillemin, Catherine L Hill, Laura L. Laslett, Graeme Jones, Flavia Cicuttini, Richard Osborne, Theo Vos, Rachelle Buchbinder, Anthony Woolf, Lyn March
Abstract: OBJECTIVE: To estimate the global burden of hip and knee osteoarthritis (OA) as part of the Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA compares with other conditions. METHODS: Systematic reviews were conducted to source age-specific and sex-specific epidemiological data for hip and knee OA prevalence, incidence and mortality risk. The prevalence and incidence of symptomatic, radiographic and self-reported hip or knee OA were included. Three levels of severity were defined to derive disability weights (DWs) and severity distribution (proportion with mild, moderate and severe OA). The prevalence by country and region was multiplied by the severity distribution and the appropriate disability weight to calculate years of life lived with disability (YLDs). As there are no deaths directly attributed to OA, YLDs equate disability-adjusted life years (DALYs). RESULTS: Globally, of the 291 conditions, hip and knee OA was ranked as the 11th highest contributor to global disability and 38th highest in DALYs. The global age-standardised prevalence of knee OA was 3.8% (95% uncertainty interval (UI) 3.6% to 4.1%) and hip OA was 0.85% (95% UI 0.74% to 1.02%), with no discernible change from 1990 to 2010. Prevalence was higher in females than males. YLDs for hip and knee OA increased from 10.5 million in 1990 (0.42% of total DALYs) to 17.1 million in 2010 (0.69% of total DALYs). CONCLUSIONS: Hip and knee OA is one of the leading causes of global disability. Methodological issues within this study make it highly likely that the real burden of OA has been underestimated. With the aging and increasing obesity of the world's population, health professions need to prepare for a large increase in the demand for health services to treat hip and knee OA.
Keywords: Humans
Osteoarthritis, Knee
Osteoarthritis, Hip
Severity of Illness Index
Regression Analysis
Age Distribution
Sex Distribution
Quality-Adjusted Life Years
Cost of Illness
Aged, 80 and over
Middle Aged
Child, Preschool
Young Adult
Global Health
Rights: © 2014 BMJ Publishing Group Ltd & European League Against Rheumatism. All rights reserved.
DOI: 10.1136/annrheumdis-2013-204763
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