Plasma 1,5-anhydro-d-glucitol concentration and its relation to other plasma components in renal failure and renal transplant recipients

Abstract

Plasma levels of 1,5-anhydro-D-glucitol (AG) were measured in non-diabetic patients with renal failure or following renal transplant. For patients with renal failure (n = 20) from various causes, the plasma level of AG was found to be positively associated with urate and negatively with both urea and prior dialysis. The results for seven renal transplant recipients, serially assessed during the post-transplant period, verified an increase in plasma AG with time, approaching normal levels (> or = 70 mumol/l) after 60 days, and which was adversely affected by rejection episodes. The actual mean rate of plasma AG rise ranged from 0.35 to 1.29 mumol/l per day. AG levels for long term (> 1000 days) surviving renal transplant recipients (n = 16) were predominantly related to renal function as assessed by plasma creatinine.