Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/87412
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Type: Journal article
Title: Control of gene expression in the P2-related template coliphages
Author: Kalionis, B.
Dodd, I.
Egan, J.
Citation: Journal of Molecular Biology, 1986; 191(2):199-209
Publisher: Elsevier
Issue Date: 1986
ISSN: 0022-2836
1089-8638
Statement of
Responsibility: 
Bill Kalionis, Ian B. Dodd, J.Barry Egan
Abstract: The PstI fragment (65.5% to 77.4%) of coliphage 186, known genetically to encode the major control genes, has been sequenced, and an analysis performed to assess coding capacity, transcription-translation signals, and to identify any other significant features. Our analysis indicates that the region encodes: (1) seven genes, including the int and cI genes, which overlap, the late control gene B, and two genes, named CP75 and CP76, encoding potential DNA-binding proteins; (2) a promoter pB and terminator tB for the rightward transcription of the B gene, and we predict the existence of this transcript in a lysogen; (3) a promoter pL and terminator tL for leftward transcription that encodes the int and cI genes, and represents the presumed lysogenic transcript; (4) a promoter pR for rightward transcription to give the presumed (early) lytic transcript that is overlapping and convergent with the lysogenic transcript; and finally (5), a potential operator site for repressor binding in the region of the pR promoter. Preliminary evidence is presented to support this analysis.
Keywords: Ribosomes; Coliphages; DNA, Viral; Transcription, Genetic; Gene Expression Regulation; Binding Sites; Base Sequence; Repetitive Sequences, Nucleic Acid; Promoter Regions, Genetic; Terminator Regions, Genetic
Rights: © 1986 Academic Press, Inc.
RMID: 0030013130
DOI: 10.1016/0022-2836(86)90257-3
Appears in Collections:Biochemistry publications

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