Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Upregulation of intestinal glucose transporters after Roux-en-Y gastric bypass to prevent carbohydrate malabsorption|
|Citation:||Obesity, 2014; 22(10):2164-2171|
|Nam Q. Nguyen, Tamara L. Debreceni, Jenna E. Bambrick, Bridgette Chia, Adam M. Deane, Gary Wittert, Chris K. Rayner, Michael Horowitz and Richard L. Young|
|Abstract:||OBJECTIVE: To determine the effect of Roux-en-Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia. METHODS: Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT-1 and GLUT2) from 11 non-diabetic RYGB, 13 non-diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3-O-methyl-d-glucopyranose (3-OMG)). Blood glucose, plasma 3-OMG, and insulin were measured for 270 min. RESULTS: In RYGB patients, expression of both GTs was ∼2-fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P < 0.001). STR expressions were comparable amongst the groups. Peak plasma 3-OMG in both RYGB (r = 0.69, P = 0.01) and obese (r = 0.72, P = 0.005) correlated with baseline expression of SGLT-1, as was the case with peak blood glucose in RYGB subjects (r = 0.69, P = 0.02). CONCLUSIONS: The upregulated intestinal GTs in RYGB patients are associated with increased glucose absorption when glucose is delivered at a physiological rate, suggesting a molecular adaptation to prevent carbohydrate malabsorption from rapid intestinal transit after RYGB.|
|Keywords:||Intestines; Humans; Malabsorption Syndromes; Obesity, Morbid; Insulin; Glucose; Blood Glucose; Gastric Bypass; Case-Control Studies; Up-Regulation; Intestinal Absorption; Adult; Middle Aged; Female; Male; Carbohydrate Metabolism; Glucose Transport Proteins, Facilitative|
|Rights:||© 2014 The Obesity Society|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.