Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Date
2010
Authors
Speliotes, E.
Palmer, L.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Nature Genetics, 2010; 42(11):937-948
Statement of Responsibility
Elizabeth K Speliotes … Lyle J Palmer … et al.
Conference Name
DOI
Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2010 Nature America, Inc. All rights reserved.