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https://hdl.handle.net/2440/88186
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Type: | Journal article |
Title: | Perinatal risk indicators for long-term neurological morbidity among preterm neonates |
Author: | Teune, M. van Wassenaer, A. van Dommelen, P. Mol, B. Opmeer, B. |
Citation: | American Journal of Obstetrics and Gynecology, 2011; 204(5):396e.1-396e.14 |
Publisher: | Mosby |
Issue Date: | 2011 |
ISSN: | 0002-9378 1097-6868 |
Statement of Responsibility: | Margreet J. Teune, Aleid G. van Wassenaer, Paula van Dommelen, Ben Willem J. Mol, Brent C. Opmeer, for the Dutch POPS-19 Collaborative Study Group |
Abstract: | Objective: Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age. Study design: Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap. Results: Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively). Conclusion: In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity. |
Keywords: | long-term neurologic morbidity; perinatal risk indicator; prediction model; premature |
Rights: | Copyright © 2011 Mosby, Inc. |
DOI: | 10.1016/j.ajog.2011.02.055 |
Published version: | http://dx.doi.org/10.1016/j.ajog.2011.02.055 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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