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Type: Journal article
Title: Lack of cross-protection against Bordetella holmesii after pertussis vaccination
Author: Zhang, X.
Weyrich, L.
Lavine, J.
Karanikas, A.
Harvill, E.
Citation: Emerging Infectious Diseases, 2012; 18(11):1771-1779
Publisher: Centers for Disease Control and Prevention
Issue Date: 2012
ISSN: 1080-6040
Statement of
Xuqing Zhang, Laura S. Weyrich, Jennie S. Lavine, Alexia T. Karanikas, and Eric T. Harvill
Abstract: Bordetella holmesii, a species closely related to B. pertussis, has been reported sporadically as a cause of whooping cough-like symptoms. To investigate whether B. pertussis-induced immunity is protective against infection with B. holmesii, we conducted an analysis using 11 human respiratory B. holmesii isolates collected during 2005-2009 from a highly B. pertussis-vaccinated population in Massachusetts. Neither whole-cell (wP) nor acellular (aP) B. pertussis vaccination conferred protection against these B. holmesii isolates in mice. Although T-cell responses induced by wP or aP cross-reacted with B. holmesii, vaccine-induced antibodies failed to efficiently bind B. holmesii. B. holmesii-specific antibodies provided in addition to wP were sufficient to rapidly reduce B. holmesii numbers in mouse lungs. Our findings suggest the established presence of B. holmesii in Massachusetts and that failure to induce cross-reactive antibodies may explain poor vaccine-induced cross-protection.
Keywords: Bordetella; Bordetella pertussis; Animals; Humans; Mice; Spleen; T-Lymphocytes; Bordetella Infections; Whooping Cough; Disease Susceptibility; Pertussis Vaccine; Antibodies, Bacterial; Phylogeny; Antibody Specificity; Adolescent; Adult; Child; Child, Preschool; Infant, Newborn; Infant; Cross Protection; Middle Aged; Young Adult; Massachusetts; Genes, Bacterial
Rights: Copyright status unknown
RMID: 0030019155
DOI: 10.3201/eid1811.111544
Appears in Collections:Microbiology and Immunology publications

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