Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/89166
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Type: Journal article
Title: A fiber-tip label-free biological sensing platform: A practical approach toward in-vivo sensing
Author: François, A.
Reynolds, T.
Monro, T.
Citation: Sensors, 2015; 15(1):1168-1181
Publisher: MDPI AG
Issue Date: 2015
ISSN: 1424-8220
1424-8220
Statement of
Responsibility: 
Alexandre François, Tess Reynolds, and Tanya M. Monro
Abstract: The platform presented here was devised to address the unmet need for real time label-free in vivo sensing by bringing together a refractive index transduction mechanism based on Whispering Gallery Modes (WGM) in dye doped microspheres and Microstructured Optical Fibers. In addition to providing remote excitation and collection of the WGM signal, the fiber provides significant practical advantages such as an easy manipulation of the microresonator and the use of this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present the first demonstration of the use of this approach for biological sensing and evaluate its limitation in a sensing configuration deprived of liquid flow which is most likely to occur in an in vivo setting. We also demonstrate the ability of this sensing platform to be operated above its lasing threshold, enabling enhanced device performance.
Keywords: Polyamines
Avidin
Staining and Labeling
Biosensing Techniques
Protein Binding
Kinetics
Coloring Agents
Optical Fibers
Optical Phenomena
Rights: This is an open access article distributed under the Creative Commons Attribution License [http://creativecommons.org/licenses/by/4.0/]which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.3390/s150101168
Appears in Collections:Aurora harvest 7
Chemistry publications

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