Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/89670
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Effects of exogenous glucagon-like peptide-1 on the blood pressure, heart rate, mesenteric blood flow, and glycemic responses to intraduodenal glucose in healthy older subjects |
Author: | Trahair, L. Horowitz, M. Hausken, T. Feinle-Bisset, C. Rayner, C. Jones, K. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2014; 99(12):E2628-E2634 |
Publisher: | Endocrine Society |
Issue Date: | 2014 |
ISSN: | 0021-972X 1945-7197 |
Statement of Responsibility: | Laurence G. Trahair, Michael Horowitz, Trygve Hausken, Christine Feinle-Bisset, Christopher K. Rayner, and Karen L. Jones |
Abstract: | Context: Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR). Objective: To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR and splanchnic blood flow in healthy older subjects. Design: Double-blind randomised trial. Setting: Community dwelling residents attending a clinical research laboratory. Patients: 10 healthy 'older' subjects (9M,1F; age 73.2 ± 1.5 yr). Interventions: Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = -30 - 60 min). Between t = 0 - 60 min, ID glucose was infused at 3 kcal/min. Main Outcome Measures: BP and HR were assessed with an automated BP device, superior mesenteric artery (SMA) flow by Doppler ultrasonography and blood glucose and serum insulin were measured. Results: During the 'fasting' period (t = -30 - 0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0 - 60 min), systolic BP decreased (P < 0.001), and both HR (P < 0.001) and SMA flow (P < 0.05) increased, on both days. GLP-1 attenuated the maximum fall in systolic BP (P < 0.05), tended to increase HR (P = 0.09) and increased SMA flow (P < 0.01). GLP-1 diminished the glycemic response (P < 0.05). Conclusions: In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow. |
Keywords: | Duodenum Mesenteric Arteries Autonomic Nervous System Humans Insulin Glucose Blood Glucose Double-Blind Method Intubation, Gastrointestinal Blood Pressure Heart Rate Splanchnic Circulation Aged Female Male Glucagon-Like Peptide 1 |
Rights: | © 2014 by the Endocrine Society |
DOI: | 10.1210/jc.2014-2475 |
Published version: | http://dx.doi.org/10.1210/jc.2014-2475 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.