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https://hdl.handle.net/2440/89755
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Type: | Conference paper |
Title: | Dietary n-3 LC-PUFA during the perinatal period as a strategy to minimize childhood allergic disease |
Author: | Makrides, M. Gunaratne, A. Collins, C. |
Citation: | Nestle Nutrition Institute workshop series, 2013 / Makrides, M., Ochoa, J., Szajewska, H. (ed./s), vol.77, pp.155-162 |
Publisher: | KARGER |
Issue Date: | 2013 |
Series/Report no.: | Nestle Nutrition Institute Workshop Series |
ISBN: | 9783318024463 |
ISSN: | 1664-2147 1664-2155 |
Conference Name: | The 77th NNI Workshop (28 Oct 2012 - 1 Nov 2012 : Panama City, FL) |
Editor: | Makrides, M. Ochoa, J. Szajewska, H. |
Statement of Responsibility: | Makrides M., Gunaratne A.W., Collins C.T. |
Abstract: | There has been growing interest in the role of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in the modulation of the immune response during early childhood and whether this may translate to a reduction in childhood allergic disease. Several randomized controlled trials of n-3 LC-PUFA supplementation have been reported, largely involving children who are at high hereditary risk of developing allergies. These studies relatively consistently indicate that supplementation during pregnancy results in fewer children with atopic eczema in early childhood. On the other hand, supplementation studies confined exclusively to the postnatal period have demonstrated mixed results with one trial showing no effect and the other suggesting a transient effect on symptoms of respiratory disease. In summary, supplementation with n-3 LC-PUFA during the perinatal period and before allergic response is established may be a useful strategy to prevent early childhood allergic disease in children at high hereditary risk. Further work is needed to establish the optimal period of supplementation and whether longer term benefits exist. |
Keywords: | Humans Hypersensitivity Dermatitis, Atopic Dietary Fats Fatty Acids, Omega-3 Diet Perinatal Care Child Child, Preschool Infant Pregnancy Dietary Supplements Female |
Rights: | Copyright © 2013 Nestec Ltd., Vevey/S. Karger AG, Basel |
DOI: | 10.1159/000351398 |
Published version: | http://dx.doi.org/10.1159/000351398 |
Appears in Collections: | Aurora harvest 2 Paediatrics publications |
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