Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/90222
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Cancer-like metabolism of the mammalian retina
Author: Ng, S.
Wood, J.
Chidlow, G.
Han, G.
Kittipassorn, T.
Peet, D.
Casson, R.
Citation: Clinical and Experimental Ophthalmology, 2015; 43(4):367-376
Publisher: Wiley
Issue Date: 2015
ISSN: 1442-6404
1442-9071
Statement of
Responsibility: 
Soo Khai Ng, John PM Wood, Glyn Chidlow, Guoge Han, Thaksaon Kittipassorn, Daniel J Peet and Robert J Casson
Abstract: The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The expanding knowledge about the molecular mechanisms underpinning the Warburg effect in cancer promises to provide a greater understanding of mammalian retinal metabolism and has motivated cancer researchers to target the Warburg effect as a novel treatment strategy for cancer. However, if the molecular mechanisms underlying the Warburg effect are shared by the retina and cancer, treatments targeting the Warburg effect may have serious adverse effects on retinal metabolism. Herein, we provide an updated understanding of the Warburg effect in mammalian retina.
Keywords: aerobic glycolysis; HIF-1; mammalian retina; PKM2; Warburg effect
Rights: © 2014 Royal Australian and New Zealand College of Ophthalmologists
RMID: 0030013105
DOI: 10.1111/ceo.12462
Appears in Collections:Biochemistry publications

Files in This Item:
File Description SizeFormat 
hdl_90222.pdfAccepted version718.8 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.