Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/91534
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Type: Journal article
Title: The inheritance of extra-hepatic portosystemic shunts and elevated bile acid concentrations in Maltese dogs
Author: O'Leary, C.
Parslow, A.
Malik, R.
Hunt, G.
Hurford, R.
Tisdall, P.
Duffy, D.
Citation: Journal of Small Animal Practice, 2014; 55(1):14-21
Publisher: Wiley
Issue Date: 2014
ISSN: 0022-4510
1748-5827
Statement of
Responsibility: 
C. A. O'Leary, A. Parslow, R. Malik, G. B. Hunt, R. I. Hurford, P. L. C. Tisdall and D. L. Duffy
Abstract: OBJECTIVES: To determine the heritability of extra-hepatic portosystemic shunts and elevated post-prandial serum bile acid concentrations in Maltese dogs. MATERIALS AND METHODS: Maltese dogs were recruited and investigated by a variable combination of procedures including dynamic bile acid testing, rectal ammonia tolerance testing, ultrasonography, portal venography, surgical inspection or necropsy. In addition, nine test matings were carried out between affected and affected dogs, and affected and unaffected dogs. RESULTS: In 135 variably related Maltese, shunt status could be confirmed in 113, including 19 with an extra-hepatic portosystemic shunt (17 confirmed at surgery, 2 at necropsy). Rectal ammonia tolerance testing results and post-prandial serum bile acid concentrations were retrievable for 50 and 88 dogs, respectively. Pedigree information was available for these 135 and an additional 164 related dogs. Two consecutive test matings were carried out between two affected animals (whose shunts had been attenuated), with 2 of 8 (25%) of offspring having an extra-hepatic portosystemic shunt. Six test matings were carried out between an affected and an unaffected animal, with 2 of 22 (9%) offspring affected. Heritability of extra-hepatic portosystemic shunt was 0·61 calculated using variance components analysis [95% confidence interval (CI) 0·14 to 1·0, P=0·001]. The best fitting model from segregation analysis was a common, partially penetrant, recessive model (allele frequency 0·34, penetrance 0·99, CI 0·09 to 1·0). The heritability of elevated post-prandial serum bile acid (and thus likely portal vein hypoplasia) was 0·81 (CI 0·43 to 1·0, P=0·2) after logarithmic transformation of post-prandial serum bile acid concentrations. CLINICAL SIGNIFICANCE: There is strong support for extra-hepatic portosystemic shunts and elevated post-prandial serum bile acid concentrations both being inherited conditions in Maltese.
Keywords: Portal Vein
Animals
Dogs
Dog Diseases
Genetic Predisposition to Disease
Bile Acids and Salts
Pedigree
Species Specificity
Female
Male
Description: Article first published online: 2 DEC 2013
Rights: © 2013 British Small Animal Veterinary Association
DOI: 10.1111/jsap.12156
Appears in Collections:Animal and Veterinary Sciences publications
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