Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9183
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dc.contributor.authorRusso, A.en
dc.contributor.authorStevens, J.en
dc.contributor.authorGiles, N.en
dc.contributor.authorKrause, G.en
dc.contributor.authorO'Donovan, D.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorJones, K.en
dc.date.issued2004en
dc.identifier.citationAlimentary Pharmacology & Therapeutics, 2004; 20(3):333-338en
dc.identifier.issn0269-2813en
dc.identifier.issn1365-2036en
dc.identifier.urihttp://hdl.handle.net/2440/9183-
dc.descriptionThe definitive version is available at www.blackwell-synergy.com Article first published online: 9 JUL 2004en
dc.description.abstractBackground: KC 11458, a motilin agonist without antibiotic properties, accelerates gastric emptying in animals and healthy humans. Aim: To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis. Methods: Twenty-nine patients (6 type 1 and 23 type 2) with gastroparesis underwent assessments of: (i) gastric emptying of a solid/liquid meal using scintigraphy, (ii) glycaemic control (blood glucose at 0, 30, 60, 90 and 120 min during the gastric emptying measurement) and (iii) upper gastrointestinal and ‘meal-related’ symptoms (questionnaire), at baseline and after treatment with KC 11458 in a dose of 8 mg t.d.s., or placebo for 8 days. Results: KC 11458 had no statistically significant or clinically relevant effect on gastric emptying of either the solid intragastric retention at 100 min (T100) (P ¼ 0.87) or liquid 50% emptying time (T50) (P ¼ 0.17) components of the meal. KC 11458 slightly worsened (P ¼ 0.04) upper gastrointestinal symptoms when compared with placebo. The magnitude of the change in solid gastric emptying correlated with the change in the blood glucose concentration (r ¼ 0.49; P < 0.05). Conclusions: KC 11458, in a dose of 8 mg t.d.s. for 8 days, does not accelerate gastric emptying in patients with diabetic gastroparesis. The absence of efficacy may relate to an effect of hyperglycaemia.en
dc.description.statementofresponsibilityA. Russo, J. E. Stevens, N. Giles, G. Krause, D. G. O’Donovan, M. Horowitz & K. L. Jonesen
dc.language.isoenen
dc.publisherBlackwell Publishing Ltden
dc.rights© 2004 Blackwell Publishing Ltden
dc.subjectHumans; Gastroparesis; Autonomic Nervous System Diseases; Diabetic Neuropathies; Diabetes Mellitus; Erythromycin; Motilin; Blood Glucose; Gastric Emptying; Middle Aged; Female; Maleen
dc.titleEffect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesisen
dc.typeJournal articleen
dc.identifier.rmid0020040740en
dc.identifier.doi10.1111/j.1365-2036.2004.02066.xen
dc.identifier.pubid56800-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
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