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https://hdl.handle.net/2440/9185
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Type: | Journal article |
Title: | Natural history of gastro-oesophageal reflux disease diagnosed in general practice |
Author: | Ruigomez, A. Garcia Rodriguez, A. Wallander, M. Johansson, S. Graffner, H. Dent, J. |
Citation: | Alimentary Pharmacology and Therapeutics, 2004; 20(7):751-760 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2004 |
ISSN: | 0269-2813 1365-2036 |
Abstract: | <h4>Background</h4>Cross-sectional studies indicate that gastro-oesophageal reflux disease symptoms have a prevalence of 10-20% in Western countries and are associated with obesity, smoking, oesophagitis, chest pain and respiratory disease.<h4>Aim</h4>To determine the natural history of gastro-oesophageal reflux disease presenting in primary care in the UK.<h4>Methods</h4>Patients with a first diagnosis of gastro-oesophageal reflux disease during 1996 were identified in the UK General Practice Research Database and compared with age- and sex-matched controls. We investigated the incidence of gastro-oesophageal reflux disease, potential risk factors and comorbidities, and relative risk for subsequent oesophageal complications and mortality.<h4>Results</h4>The incidence of a gastro-oesophageal reflux disease diagnosis was 4.5 per 1000 person-years (95% confidence interval: 4.4-4.7). Prior use of non-steroidal anti-inflammatory drugs, smoking, excess body weight and gastrointestinal and cardiac conditions were associated with an increased risk of gastro-oesophageal reflux disease diagnosis. Subjects with gastro-oesophageal reflux disease had an increased risk of respiratory problems, chest pain and angina in the year after diagnosis, and had a relative risk of 11.5 (95% confidence interval: 5.9-22.3) of being diagnosed with an oesophageal complication. There was an increase in mortality in the gastro-oesophageal reflux disease cohort only in the year following the diagnosis.<h4>Conclusions</h4>Gastro-oesophageal reflux disease is a disease associated with a range of potentially serious oesophageal complications and extra-oesophageal diseases. |
Keywords: | Humans Gastroesophageal Reflux Nitrates Steroids Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Risk Factors Cohort Studies Family Practice Adolescent Adult Aged Middle Aged Child Child, Preschool Infant Patient Acceptance of Health Care Female Male United Kingdom |
DOI: | 10.1111/j.1365-2036.2004.02169.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2036.2004.02169.x |
Appears in Collections: | Aurora harvest Medicine publications |
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