Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men
Author: MacIntosh, C.
Horowitz, M.
Verhagen, M.
Smout, A.
Wishart, J.
Morris, H.
Goble, E.
Morley, J.
Chapman, I.
Citation: American Journal of Gastroenterology, 2001; 96(4):997-1007
Publisher: Elsevier Science Inc
Issue Date: 2001
ISSN: 0002-9270
Statement of
Caroline G. MacIntosh, Michael Horowitz, Marc A. M. T. Verhagen, Andre J. P. M. Smout, Judith Wishart, Howard Morris, Elizabeth Goble, John E. Morley, and Ian M. Chapman
Abstract: <h4>Objective</h4>The mechanisms responsible for the reduction in appetite and slowing of gastric emptying in older persons are poorly understood. The aim of this study was to evaluate the effects of aging on small intestinal regulation of appetite, GI hormone release, and gastric myoelectrical activity.<h4>Methods</h4>Thirteen older (65-84 yr) and 13 young (18-32 yr) healthy men received isovolumetric, intraduodenal (i.d.) infusions of saline (control), lipid, and glucose for 120 min, on separate days. The energy content of the lipid and glucose infusions was identical at 2.86 kcal/min. Immediately after the i.d. infusions, each subject was offered a buffet meal, and ad libitum food intake was quantified. Blood glucose and plasma insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide were measured. Gastric myoelectrical activity was measured by surface electrogastrography (EGG).<h4>Results</h4>I.d. lipid suppressed food intake in both the young and older men (p < 0.05), whereas i.d. glucose suppressed food intake only in the older men (p < 0.05). The blood glucose (p < 0.01) and insulin (p < 0.05) responses to i.d. glucose were greater in older than young men. However, there were no differences in glucagon-like peptide 1 or glucose-dependent insulinotropic peptide responses to any of the infusions. There was a greater increase in the EGG power ratio both during and after i.d. glucose infusion in the young (p < 0.05) than the older men, and an attenuation of EGG frequency by nutrient infusions in older, but not young, men.<h4>Conclusions</h4>Our findings indicate that aging is associated with nutrient-specific changes in appetite, hormonal, and gastric myoelectrical (EGG) responses to i.d. nutrients. An enhanced satiating effect of small intestinal carbohydrates may potentially contribute to the anorexia of aging.
Keywords: Intestine, Small
Gastric Inhibitory Polypeptide
Blood Glucose
Peptide Fragments
Protein Precursors
Enteral Nutrition
Age Factors
Energy Intake
Myoelectric Complex, Migrating
Aged, 80 and over
Glucagon-Like Peptide 1
Description: © 2001 by American College of Gastroenterology
DOI: 10.1111/j.1572-0241.2001.03684.x
Appears in Collections:Aurora harvest
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.