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|Title:||A longitudinal study of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus|
|Citation:||American Journal of Medicine, 2002; 113(6):449-455|
|Publisher:||Excerpta Medica Inc|
|Karen L. Jones, Antonietta Russo, Melanie K. Berry, Julie E. Stevens, Judith M. Wishart, Michael Horowitz|
|Abstract:||PURPOSE:To evaluate the natural history of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus. SUBJECTS AND METHODS:We enrolled 20 patients (6 men, 14 women) with diabetes mellitus (16 with type 1 diabetes, 4 with type 2 diabetes). Each had measurements of gastric emptying of a solid (100 g of ground beef) and liquid (150 mL of 10% dextrose) meal using scintigraphy, glycemic control (glycosylated hemoglobin [HbA(1c)] and mean blood glucose levels), upper gastrointestinal symptoms, and autonomic nerve function at baseline and after a mean (+/- SD) of 12.3 +/- 3.1 years of follow-up. RESULTS:There were no differences in mean gastric emptying of the solid component (retention at 100 minutes at baseline: 56% +/- 19% vs. follow-up: 51% +/- 21%, P = 0.23) or the liquid component (time for 50% to empty at baseline: 33 +/- 11 minutes vs. follow-up: 31 +/- 12 minutes, P = 0.71) during follow-up. Mean blood glucose (17.0 +/- 5.6 mmol/L vs. 13.8 +/- 4.9 mmol/L, P = 0.007) and HbA(1c) (8.4% +/- 2.3% vs. 7.6% +/- 1.3%, P = 0.03) levels were lower at follow-up. There was no difference in symptom score (baseline: 3.9 +/- 2.7 vs. follow-up: 4.2 +/- 4.0, P = 0.78). There was evidence of autonomic neuropathy in 7 patients (35%) at baseline and 16 (80%) at follow-up. CONCLUSION:In patients with diabetes mellitus, we did not observe any marked changes in either gastric emptying or upper gastrointestinal symptoms during a 12-year period.|
|Keywords:||Humans; Gastrointestinal Diseases; Gastroparesis; Diabetic Neuropathies; Diabetes Mellitus; Diabetes Complications; Blood Glucose; Longitudinal Studies; Gastric Emptying; Middle Aged; Female; Male|
|Rights:||Copyright © 2002 by Excerpta Medica, Inc.|
|Appears in Collections:||Medicine publications|
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