Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9242
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Relative contributions of "pressure pump" and "peristaltic pump" to gastric emptying
Author: Indireschkumar, K.
Brasseur, J.
Faas, H.
Hebbard, G.
Kunz, P.
Dent, J.
Feinle-Bisset, C.
Li, M.
Boesiger, P.
Fried, M.
Schwizer, W.
Citation: American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000; 278(4 41-4):G604-G616
Publisher: Amer Physiological Soc
Issue Date: 2000
ISSN: 0193-1857
1522-1547
Statement of
Responsibility: 
Indireshkumar, K ; Brasseur, J G ; Faas, H ; Hebbard, G S ; Kunz, P ; Dent, J ; Feinle, C ; Li, M ; Boesiger, P ; Fried, M ; Schwizer, W
Abstract: The relative contributions to gastric emptying from common cavity antroduodenal pressure difference ("pressure pump") vs. propagating high-pressure waves in the distal antrum ("peristaltic pump") were analyzed in humans by high-resolution manometry concurrently with time-resolved three-dimensional magnetic resonance imaging during intraduodenal nutrient infusion at 2 kcal/min. Gastric volume, space-time pressure, and contraction wave histories in the antropyloroduodenal region were measured in seven healthy subjects. The subjects fell into two distinct groups with an order of magnitude difference in levels of antral pressure activity. However, there was no significant difference in average rate of gastric emptying between the two groups. Antral pressure history was separated into "propagating high-pressure events" (HPE), "nonpropagating HPEs," and "quiescent periods." Quiescent periods dominated, and average pressure during quiescent periods remained unchanged with decreasing gastric volume, suggesting that common cavity pressure levels were maintained by increasing wall muscle tone with decreasing volume. When propagating HPEs moved to within 2-3 cm of the pylorus, pyloric resistance was found statistically to increase with decreasing distance between peristaltic waves and the pylorus. We conclude that transpyloric flow tends to be blocked when antral contraction waves are within a "zone of influence" proximal to the pylorus, suggesting physiological coordination between pyloric and antral contractile activity. We further conclude that gastric emptying of nutrient liquids is primarily through the "pressure pump" mechanism controlled by pyloric opening during periods of relative quiescence in antral contractile wave activity.
Keywords: Duodenum; Pyloric Antrum; Pylorus; Humans; Magnetic Resonance Imaging; Manometry; Gastrointestinal Motility; Gastric Emptying; Peristalsis; Pressure; Adult; Middle Aged; Female; Male
RMID: 0001002069
DOI: 10.1152/ajpgi.2000.278.4.g604
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.