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https://hdl.handle.net/2440/92579
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dc.contributor.author | Hughes, A. | - |
dc.contributor.author | Rojas-Canales, D. | - |
dc.contributor.author | Drogemuller, C. | - |
dc.contributor.author | Voelcker, N. | - |
dc.contributor.author | Grey, S. | - |
dc.contributor.author | Coates, P. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Endocrinology, 2014; 221(2):R41-R48 | - |
dc.identifier.issn | 0022-0795 | - |
dc.identifier.issn | 1479-6805 | - |
dc.identifier.uri | http://hdl.handle.net/2440/92579 | - |
dc.description.abstract | In the week following pancreatic islet transplantation, up to 50% of transplanted islets are lost due to apoptotic cell death triggered by hypoxic and pro-inflammatory cytokine-mediated cell stress. Thus, therapeutic approaches designed to protect islet cells from apoptosis could significantly improve islet transplant success. IGF2 is an anti-apoptotic endocrine protein that inhibits apoptotic cell death through the mitochondrial (intrinsic pathway) or via antagonising activation of pro-inflammatory cytokine signalling (extrinsic pathway), in doing so IGF2 has emerged as a promising therapeutic molecule to improve islet survival in the immediate post-transplant period. The development of novel biomaterials coated with IGF2 is a promising strategy to achieve this. This review examines the mechanisms mediating islet cell apoptosis in the peri- and post-transplant period and aims to identify the utility of IGF2 to promote islet survival and enhance long-term insulin independence rates within the setting of clinical islet transplantation. | - |
dc.description.statementofresponsibility | Amy Hughes, Darling Rojas-Canales, Chris Drogemuller, Nicolas H Voelcker, Shane T Grey and P T H Coates | - |
dc.language.iso | en | - |
dc.publisher | BioScientifica | - |
dc.rights | © 2014 Society for Endocrinology | - |
dc.source.uri | http://dx.doi.org/10.1530/joe-13-0557 | - |
dc.subject | insulin-like growth factor; apoptosis; islets; cell survival; islet transplantation | - |
dc.title | IGF2: an endocrine hormone to improve islet transplant survival | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1530/JOE-13-0557 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Drogemuller, C. [0000-0001-9770-4845] | - |
dc.identifier.orcid | Grey, S. [0000-0003-2160-1625] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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