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dc.contributor.authorWilkinson, R.-
dc.contributor.authorLyons, A.-
dc.contributor.authorRoberts, D.-
dc.contributor.authorWong, M.-
dc.contributor.authorBartley, P.-
dc.contributor.authorJackson, D.-
dc.identifier.citationBlood, 2002; 100(1):184-193-
dc.descriptionCopyright © 2002 by The American Society of Hematology.-
dc.description.abstractPlatelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an immunoglobulin-immunoreceptor tyrosine-based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, SHP-1 and SHP-2, through its intrinsic ITIMs. PECAM-1-deficient (PECAM-1(-/-) ) mice exhibit a hyperresponsive B-cell phenotype, increased numbers of B-1 cells, reduced B-2 cells, and develop autoantibodies. In the periphery, there are reduced mature recirculating B-2 cells and increased B-1a cells within the peritoneal cavity. In addition, PECAM-1(-/-) B cells display hyperproliferative responses to lipopolysaccharide and anti-IgM stimulation and showed enhanced kinetics in their intracellular Ca(++) response following IgM cross-linking. PECAM-1(-/-) mice showed increased serum levels of IgM with elevated IgG isotypes and IgA antidinitrophenol antibody in response to the T-independent antigen, dinitrophenol-Ficoll. Finally, PECAM-1(-/-) mice developed antinuclear antibodies and lupuslike autoimmune disease with age.-
dc.description.statementofresponsibilityRay Wilkinson, A. Bruce Lyons, Donna Roberts, Mae-Xhum Wong, Paul A. Bartley, and Denise E. Jackson-
dc.publisherAmer Soc Hematology-
dc.subjectBone Marrow-
dc.subjectMice, Knockout-
dc.subjectAutoimmune Diseases-
dc.subjectReceptors, Antigen, B-Cell-
dc.subjectLymphocyte Activation-
dc.subjectCalcium Signaling-
dc.subjectAntibody Formation-
dc.subjectPlatelet Endothelial Cell Adhesion Molecule-1-
dc.titlePlatelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease-
dc.typeJournal article-
dc.identifier.orcidLyons, A. [0000-0002-8508-5853]-
dc.identifier.orcidRoberts, D. [0000-0002-8292-2142]-
Appears in Collections:Aurora harvest
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