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https://hdl.handle.net/2440/9305
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Wilkinson, R. | - |
dc.contributor.author | Lyons, A. | - |
dc.contributor.author | Roberts, D. | - |
dc.contributor.author | Wong, M. | - |
dc.contributor.author | Bartley, P. | - |
dc.contributor.author | Jackson, D. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Blood, 2002; 100(1):184-193 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9305 | - |
dc.description | Copyright © 2002 by The American Society of Hematology. | - |
dc.description.abstract | Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an immunoglobulin-immunoreceptor tyrosine-based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, SHP-1 and SHP-2, through its intrinsic ITIMs. PECAM-1-deficient (PECAM-1(-/-) ) mice exhibit a hyperresponsive B-cell phenotype, increased numbers of B-1 cells, reduced B-2 cells, and develop autoantibodies. In the periphery, there are reduced mature recirculating B-2 cells and increased B-1a cells within the peritoneal cavity. In addition, PECAM-1(-/-) B cells display hyperproliferative responses to lipopolysaccharide and anti-IgM stimulation and showed enhanced kinetics in their intracellular Ca(++) response following IgM cross-linking. PECAM-1(-/-) mice showed increased serum levels of IgM with elevated IgG isotypes and IgA antidinitrophenol antibody in response to the T-independent antigen, dinitrophenol-Ficoll. Finally, PECAM-1(-/-) mice developed antinuclear antibodies and lupuslike autoimmune disease with age. | - |
dc.description.statementofresponsibility | Ray Wilkinson, A. Bruce Lyons, Donna Roberts, Mae-Xhum Wong, Paul A. Bartley, and Denise E. Jackson | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Hematology | - |
dc.source.uri | http://bloodjournal.hematologylibrary.org/cgi/content/abstract/100/1/184 | - |
dc.subject | B-Lymphocytes | - |
dc.subject | Bone Marrow | - |
dc.subject | Animals | - |
dc.subject | Mice, Knockout | - |
dc.subject | Mice | - |
dc.subject | Autoimmune Diseases | - |
dc.subject | Receptors, Antigen, B-Cell | - |
dc.subject | Autoantibodies | - |
dc.subject | Lymphocyte Activation | - |
dc.subject | Apoptosis | - |
dc.subject | Calcium Signaling | - |
dc.subject | Antibody Formation | - |
dc.subject | Platelet Endothelial Cell Adhesion Molecule-1 | - |
dc.title | Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1182/blood-2002-01-0027 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lyons, A. [0000-0002-8508-5853] | - |
dc.identifier.orcid | Roberts, D. [0000-0002-8292-2142] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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