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https://hdl.handle.net/2440/9329
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Type: | Journal article |
Title: | A novel BCR-ABL transcript (e8a2) with the insertion of an inverted sequence of ABL intron 1b in a patient with Philadelphia-positive chronic myeloid leukaemia |
Author: | Branford, S. Rudzi, Z. Hughes, T. |
Citation: | British Journal of Haematology, 2000; 109(3):635-637 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2000 |
ISSN: | 0007-1048 1365-2141 |
Abstract: | An atypical BCR-ABL transcript in a patient with Philadelphia (Ph)-positive chronic myeloid leukaemia (CML) was detected using a long polymerase chain reaction technique. Sequence analysis revealed a joining of BCR exon e8 and ABL exon a2, with a 55-base pair (bp) insert of an inverted sequence of ABL intron 1b between them, giving rise to an in frame e8a2 BCR-ABL transcript. This is the first report of a BCR-ABL transcript with the insertion of an inverted sequence. The long PCR technique is a useful screen for atypical BCR-ABL transcripts not detected by standard techniques. |
Keywords: | Humans Fusion Proteins, bcr-abl Electrophoresis, Agar Gel Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Transcription, Genetic Exons Middle Aged Male Artificial Gene Fusion Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
DOI: | 10.1046/j.1365-2141.2000.02042.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2141.2000.02042.x |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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